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Pituitary Tumor-Transforming 1 (PTTG1) antibody
| Antigen | Pituitary Tumor-Transforming 1 (PTTG1) |
| Synonyms | EAP1, PTTG, HPTTG, TUTR1, MGC126883, MGC138276, PTTG1, MGC127932, MGC134134 |
| Clonality | Polyclonal |
| Host |
 Alternatives Rabbit |
| Reactivity |
Alternatives Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Pig (Porcine) |
| Application |
Alternatives Western Blotting (WB)
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1 reference available |
| Catalog no. | ABIN183654 |
| Quantity | 0.1 mg (Variants) |
| Price | Product not available in this region. |
| Shipping to |
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Additional Information
| Alternative name | Securin / PTTG1 |
| Description | PTTG1 is a homolog of yeast securing proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. PTTG1 has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. PTTG1 contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Keywords: PTTG1, pituitary tumor-transforming 1, ARP38424_T100, NP_004210, NM_004219, O95997, EAP1, HPTTG, MGC126883, MGC138276, PTTG, SECURIN, TUTR1 |
Application Details
| Application Notes | ELISA titre: 1:1562500 . Western Blotting: Suggested dilution at 2.5 ug/ml in 5% skim milk / PBS buffer, and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50,000 - 100,000 as second antibody. |
| Restrictions | For Research Use only |
Publications
| Publications |
Kim, Pemberton, Stratford et al.: "Pituitary tumour transforming gene (PTTG) induces genetic instability in thyroid cells." in: Oncogene, Vol. 24, Issue 30, pp. 4861-6, 2005 (PubMed).
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Alternatives
Alternatives for antigen "Pituitary Tumor-Transforming 1 (PTTG1)", type "Antibodies"
| Hosts | Mouse (18), Rabbit (8) |
| Reactivities | Human (26), Mouse (Murine) (1), Rat (Rattus) (1) |
| Applications | Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (12), Western Blotting (WB) (10), Enzyme Immunoassay (EIA) (7), Immunofluorescence (IF) (4), ELISA (Detection) (3), ELISA (2), Immunohistochemistry (IHC) (2), Immunoprecipitation (IP) (2), Flow Cytometry (FACS) (1), Immunocytochemistry (ICC) (1) |
| Epitopes | N-Term (1) |
