GATAD2B antibody (N-Term)

Catalog No. ABIN183798

Product Details anti-GATAD2B Antibody

Target: GATAD2B (GATA Zinc Finger Domain Containing 2B (GATAD2B))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Guinea Pig, Dog, Horse, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GATAD2B antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MDRMTEDALR LNLLKRSLDP ADERDDVLAK RLKMEGHEAM ERLKMLALLK

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against GATAD2B. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human GATAD2B

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 593 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for GATAD2B

Target: GATAD2B (GATA Zinc Finger Domain Containing 2B (GATAD2B))

Alternative Name: GATAD2B (GATAD2B Products)

Synonyms: GATAD2B antibody, MRD18 antibody, P66beta antibody, RP11-216N14.6 antibody, p68 antibody, AL118180 antibody, C430014D17Rik antibody, mKIAA1150 antibody, RGD1308533 antibody, GATA zinc finger domain containing 2B antibody, GATAD2B antibody, gatad2b antibody, Gatad2b antibody

Background: Hp66beta (GATAD2B), previously identified as a component of the human MeCP1 complex, is a second member of a p66 gene family (hp66alpha and hp66beta). Both proteins interact with MBD2 and MBD3 functionally and biochemically. Both factors function in synergy, since knocking-down p66alpha affects the repressive function of p66beta and vice versa. Furthermore, confocal microscopy shows a nuclear colocalization of hp66alpha with hp66beta and MBD2 in a speckled pattern. These two highly related mammalian p66 proteins display overlapping functions and are involved in methylation dependent transcriptional repression.
Alias Symbols: P66beta, RP11-216N14.6
Protein Interaction Partner: USHBP1, CEP70, RPGRIP1, TEX11, MBD3, TRIM27, PRKAB2, GOLGA2, CALCOCO2, TRAF1, SUMO2, UBC, ZBTB1, SUZ12, EED, RNF2, HDAC2, HDAC1, SMAD2, MTA3, NOTCH1, MTA2, MTA1, NDUFA7, NDUFA2, SOX2, PARK7, tat, HIST1H4A, HIST1H3A, HIST2H2BE, HIST2H2AC, RBBP7, RBBP4, Fox
Protein Size: 593

Molecular Weight: 65 kDa

Gene ID: 57459

NCBI Accession: NM_020699, NP_065750

UniProt: Q8WXI9