Tyrosyl-tRNA Synthetase (Yars) (C-Term) antibody

Details for Product No. ABIN183962
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Antigen
Synonyms cmtdic, tyrrs, yrs, yts, YARS, CG4561, Dmel\\CG4561, TyrRS, YRS, anon-EST:Posey261, dYARS, GB10789, ECK1633, JW1629, cb204, wu:fk52b08, CMTDIC, TYRRS, YTS, AL024047, AU018965
Epitope
C-Term
(7), (6), (4), (2), (2), (2), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Dog (Canine), Cow (Bovine), Zebrafish (Danio rerio), Human, Chicken
(38), (5), (3), (2), (1), (1)
Host
Rabbit
(32), (6)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (4), (4)
Application
Western Blotting (WB)
(38), (22), (7), (5), (4), (3), (3), (2), (2), (1)
Pubmed 1 reference available
Quantity 100 μg
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Catalog No. ABIN183962
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Immunogen Synthetic peptide directed towards the C terminal of human YARS
Sequence QVEPLDPPAG SAPGEHVFVK GYEKGQPDEE LKPKKKVFEK LQADFKISEE
Predicted Reactivity Bovine : 100 %, Dog : 100 %, Horse : 100 %, Mouse : 100 %, Rabbit : 100 %, Rat : 100 %, Chicken : 70 %, Zebrafish : 70 %
Characteristics This is a rabbit polyclonal antibody against YARS. It was validated on Western Blot using a cell lysate as a positive control.
Purification Protein A purified
Alternative Name YARS
Background Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine.Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine.
Molecular Weight 58 kDa
Gene ID 8565
NCBI Accession NP_003671, NM_003680
UniProt P54577
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 528 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Tyrosyl-tRNA Synthetase (Yars) (C-Term) antibody WB Suggested Anti-YARS Antibody Titration: 2.5ug/ml
Positive Control: Jurkat cell lysate
Background publications Jordanova, Irobi, Thomas et al.: "Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy." in: Nature genetics, Vol. 38, Issue 2, pp. 197-202, 2006 (PubMed).

Validation Images
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