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Details for Product No. ABIN184072

Exosome Component 6 (EXOSC6) (N-Term) antibody

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Antigen
Synonyms p11, EAP4, MTR3, Mtr3p, hMtr3p, 2610510N21Rik, C76919, Mtr3, id:ibd1130, wu:fe17d05, zgc:110071, exosc6, RAR-gamma
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Mouse (Murine), Rat (Rattus), Dog (Canine), Cow (Bovine), Zebrafish (Danio rerio), Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN184072
Quantity 50 µg
Price
289.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen The immunogen for anti-EXOSC6 antibody: synthetic peptide directed towards the N terminal of human EXOSC6
Sequence LYAADEEEAPGTRDPTRLRPVYARAGLLSQAKGSAYLEAG GTKVLCAVSG
Predicted Reactivity Bovine : 100%, Rat : 100%
Characteristics This is a rabbit polyclonal antibody against EXOSC6. It was validated on Western Blot using a cell lysate as a positive control. We strive to provide antibodies covering each member of a whole protein family of your interest.
Purification Affinity Purified
Alternative Name EXOSC6
Background EXOSC6 constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation.This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation.
Molecular Weight 30kDa
Gene ID 118460
NCBI Accession NP_478126, NM_058219
UniProt Q5RKV6
Research Area Chromatin and Nuclear Signaling, DNA/RNA
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-EXOSC6 antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Background publications Raijmakers, Egberts, van Venrooij et al.: "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring." in: Journal of molecular biology, Vol. 323, Issue 4, pp. 653-63, 2002 (PubMed).

Alternatives for antigen "Exosome Component 6 (EXOSC6)", type "Antibodies"
Hosts (8)
Reactivities (6), (1), (1), (1), (1)
Applications (8), (3)
Epitopes (6), (3)
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