Interferon Regulatory Factor 8 (IRF8) (N-Term) antibody

Details for Product No. ABIN184318
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Antigen
Synonyms zgc:92252, IRF8, MGC140338, DKFZp469B0320, H-ICSBP, ICSBP, ICSBP1, IRF-8, icsbp1, AI893568, Icsbp1, Myls
Epitope
N-Term
(27), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Cow (Bovine), Human, Mouse (Murine), Rat (Rattus), Dog (Canine), Zebrafish, Chicken, Xenopus laevis
(49), (27), (17), (3), (2), (1), (1), (1)
Host
Rabbit
(48), (8), (1)
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(52), (22), (9), (8), (7), (7), (4), (2), (1)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN184318
289.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human IRF8
Sequence MFRIPWKHAG KQDYNQEVDA SIFKAWAVFK GKFKEGDKAE PATWKTRLRC
Cross-Reactivity Cow (Bovine), Dog (Canine), Chicken, Human, Mouse (Murine), Rat (Rattus)
Predicted Reactivity African clawed frog : 100 %, Bovine : 100 %, Chicken : 100 %, Dog : 100 %, Guinea pig : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rabbit : 100 %, Rat : 100 %, Zebrafish : 100 %
Purification Affinity Purified
Alternative Name IRF8 / ICSBP1
Background Interferon regulatory factor 8 (IRF8, interferon consensus sequence-binding protein, Ion ChannelSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-. and IFN-.. IRF family proteins also control expression of IFN-. and IFN-.-regulated genes that are induced by viral infection.
Molecular Weight 48 kDa
NCBI Accession NM_002163, NP_002154
UniProt Q02556
Research Area Immunology, Innate Immunity, Transcription Factors
Application Notes WB Suggested Anti-IRF8 Antibody Titration: 0.2-1 µg/mL
ELISA Titer: 1:62500
Positive Control: Jurkat cell lysate.
Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 426 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage 4 °C
Storage Comment Any unfrozen and/or unused material can be stored at 4 °C for short term use (< 1 week), and should not be re-frozen. For longer periods of storage, store at -24 °C
Supplier Images
anti-Interferon Regulatory Factor 8 (IRF8) (N-Term) antibody WB Suggested Anti-IRF8 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Jurkat cell lysate
anti-Interferon Regulatory Factor 8 (IRF8) (N-Term) antibody (2) anti-Interferon Regulatory Factor 8 (IRF8) (N-Term) antibody (Image 2)
anti-Interferon Regulatory Factor 8 (IRF8) (N-Term) antibody (3) anti-Interferon Regulatory Factor 8 (IRF8) (N-Term) antibody (Image 3)
Background publications Weisz, Marx, Sharf et al.: "Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes." in: The Journal of biological chemistry, Vol. 267, Issue 35, pp. 25589-96, 1993 (PubMed).

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