×
For best experience we recommend to activate Javascript in your browser.
VAV1 antibody (AA 121-324)
VAV1
Reactivity: Human
WB, ELISA, FACS
Host: Mouse
Monoclonal
unconjugated
Product Details anti-VAV1 Antibody
(hide)
Target
See all VAV1 Antibodies
VAV1
(Vav 1 Oncogene (VAV1))
Binding Specificity
All epitopes for VAV1 antibodies
AA 121-324
Reactivity
All reactivities for VAV1 antibodies
Human
Host
All hosts for VAV1 antibodies
Mouse
Clonality
All clonalities for VAV1 antibodies
Monoclonal
Conjugate
All conjugates for VAV1 antibodies
This VAV1 antibody is un-conjugated
Application
All applications for VAV1 antibodies
Western Blotting (WB), ELISA, Flow Cytometry (FACS)
Purification
Purified antibody
Immunogen
Purified recombinant fragment of human VAV1 (AA: 121-324) expressed in E. Coli.
Isotype
IgG1
Top Product
Discover our top product VAV1 Primary Antibody
Alternatives
(show)
Application Details
(hide)
Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
(hide)
Format
Liquid
Concentration
1.0 mg/mL
Buffer
PBS with 0.05 % sodium azide and 0.5 % protein stabilizer.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Target Details for VAV1
(hide)
Target
VAV1
(Vav 1 Oncogene (VAV1))
Alternative Name
VAV1 (VAV1 Products )
Synonyms
VAV antibody, Vav antibody, vav-T antibody, vav guanine nucleotide exchange factor 1 antibody, vav 1 oncogene antibody, vav guanine nucleotide exchange factor 1 L homeolog antibody, VAV1 antibody, Vav1 antibody, vav1.L antibody
Background
The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.
Molecular Weight
98.3 kDa
Gene ID
7409
UniProt
P15498
Pathways
TCR Signaling , Fc-epsilon Receptor Signaling Pathway , EGFR Signaling Pathway , Neurotrophin Signaling Pathway , CXCR4-mediated Signaling Events , BCR Signaling
Recently viewed
(hide)