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Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (Isoform 1, Isoform 2) antibody

Antigen

Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3)
Synonyms APRF, HIES, FLJ20882, MGC16063, fc15d02, fl59g06, z-Stat3, MGC193054, wu:fc15d02, wu:fl59g06, STAT3, DKFZp469E1221
Binding Site
Alternatives

Isoform 1, Isoform 2
Clonality Polyclonal
Host
Reactivity
Alternatives

Mouse (Murine)
Conjugate
Alternatives Un-conjugated
Application
Alternatives ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
1 reference available
Catalog no. ABIN184593
Quantity 100 ug
Price 374.27 $   Plus shipping costs $45.00
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anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (Isoform 1, Isoform 2) antibody

anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (Isoform 1, Isoform 2) antibody (2)

Additional Information
Application Details Publications Images Alternatives back to top

Alternative name STAT3
Gene ID 6774, 20848 (mouse), 25125 (rat)
Immunogen DMELTSECATSPM
Description All names and symbols: STAT3, signal transducer and activator of transcription 3 (acute-phase response factor), APRF, DNA-binding protein APRF, acute-phase response factor, FLJ20882, MGC16063. Official Symbol: STAT3. RefSeq number(s): NP_003141.2, NP_644805.1. Gene ontology terms: hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity, transcription factor activity, JAK-STAT cascade, acute-phase response, neurogenesis, cell motility, signal transduction, regulation of transcription from Pol II promoter, negative regulation of transcription from Pol II promoter, cytoplasm, nucleus
Specificity This antibody is expected to recognise isoforms 1 and 2 (as represented by NP_644805.1 and NP_003141.2 respectively) Human, Mouse, Rat

Application Details
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Application Notes Peptide ELISA: antibody detection limit dilution 1:128,000. Western Blot: Approx. 90kDa band observed in lysates of NIH3T3 (calculated MW of 88.0kDa according to NP_644805.1 and of 88.1 according to NP_003141.2). Recommended concentration: 1-3µg/ml. Immunohistochemistry: Stains mouse thymic medulla and not the cortex. Recommended overnight staining at 10ug/ml, see picture.
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Buffer 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Storage Aliquot and store at -20°C. Minimize freezing and thawing.
Restrictions For Research Use only

Publications
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Bromberg, Wrzeszczynska, Devgan et al.: "Stat3 as an oncogene." in: Cell, Vol. 98, Issue 3, pp. 295-303, 1999 (PubMed).

Alternatives
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Alternatives for antigen "Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3)", type "Antibodies"
Hosts Rabbit (208), Mouse (36), Goat (10), Sheep (1)
Reactivities Human (228), Mouse (Murine) (151), Rat (Rattus) (135), Dog (Canine) (66), Cow (Bovine) (63), Chicken (57), Pig (Porcine) (57), Guinea Pig (54), Sheep (Ovine) (54), Monkey (5), Xenopus laevis (2), Chimpanzee (1), Hamster (1), Rhesus Monkey (1), Zebrafish (1), Zebrafish (Danio rerio) (1)
Applications Western Blotting (WB) (188), ELISA (97), Immunofluorescence (IF) (73), Immunohistochemistry (IHC) (73), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (50), Immunoprecipitation (IP) (40), Immunocytochemistry (ICC) (28), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (11), Flow Cytometry (FACS) (9), Immunohistochemistry (Frozen Sections) (IHC (fro)) (5), Gel Shift (GS) (3), Immunoelectron Microscopy (IEM) (3), Fluorescence Microscopy (FM) (2), Immunoassay (IA) (2), Cellular Assay (CA) (1), Dot Blot (Dot) (1), Electrophoretic Mobility-Shift Assay (EMSA) (1), Enzyme Immunoassay (EIA) (1), Immunostaining (ISt) (1)
Conjugates Biotin (8), FITC (5), Alexa Fluor 647 (4), PE (4), Alexa Fluor 350 (3), Alexa Fluor 488 (3), Alexa Fluor 555 (3), Cy3 (3), Cy5 (3), Cy5.5 (3), Cy7 (3), Gold (3), HRP (3), PE,Cy3 (3), PE,Cy5 (3), PE,Cy5.5 (3), PE,Cy7 (3), CF (1)
Epitopes pTyr705 (45), pSer727 (41), C-Term (34), AA 50-240 (6), Ser727 (4), N-Term (3), pTyr705,C-Term (3), Internal Region (2), Tyr705 (2), pTyr705,Internal Region (2), AA 1-170 (1), AA 1-175 (1), AA 154-175 (1), AA 688-722 (1), AA 703-714,pTyr705 (1), C-Term,AA 673-699 (1), C-Term,AA 711-743 (1), Isoform 1, Isoform 2 (1), Isoform 1,C-Term (1), Phosphospecific (1), Ser721 (1), Transcript Variant 3 (1), pTyr690 (1), pTyr701 (1), pTyr727 (1), phospho (1)