Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1) antibody

Details for Product No. ABIN184837
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Antigen
Reactivity
Human
(135), (50), (36), (3), (2), (2), (1), (1), (1), (1), (1)
Host
Goat
(107), (27), (16)
Clonality
Polyclonal
Conjugate
Un-conjugated
(7), (5), (5), (5), (5), (5), (2), (2), (2), (2), (2), (2), (2), (2)
Application
ELISA
(126), (74), (20), (18), (17), (11), (10), (6), (5), (5), (4), (1), (1)
Pubmed 1 reference available
Quantity 100 μg
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Immunogen C-PPEPQPPVTPDAL
Specificity Human 977 aa
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Alternative Name IRE1 / ERN1 (ERN1 Antibody Abstract)
Background All names and symbols: ERN1, endoplasmic reticulum to nucleus signalling 1, FLJ30999, IRE1, IRE1P, MGC163277, MGC163279, ER to nucleus signalling 1, inositol-requiring 1, protein kinase/endoribonuclease. Official Symbol: ERN1. RefSeq number(s): NP_001424.3. Gene ontology terms: endoribonuclease activity, ATP binding, protein serine/threonine kinase activity, DNA binding, electron transport, protein amino acid phosphorylation, endoplasmic reticulum membrane, nucleus, transferase activity
Gene ID 2081
Application Notes Peptide ELISA: antibody detection limit dilution 1:4,000. Western Blot: No signal obtained yet but low background observed in HepG2 lysates at up to 2µg/ml. We would appreciate any feedback from people in the field - have any results been reported with other antibodies/lysates?
Restrictions For Research Use only
Format Liquid
Buffer 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
General Tirasophon, Welihinda, Kaufman: "A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells." in: Genes & development, Vol. 12, Issue 12, pp. 1812-24, 1998 (PubMed).

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Catalog No. ABIN184837
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