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NLRP3 antibody (NLR Family, Pyrin Domain Containing 3) (C-Term)

Details for Product anti-NLRP3 Antibody No. ABIN184887, Supplier: Log in to see
Antigen
  • CIAS1
  • Nalp3
  • avp
  • cias1
  • nalp3
  • pypaf1
  • agtavprl
  • AGTAVPRL
  • AII
  • AVP
  • C1orf7
  • CLR1.1
  • FCAS
  • FCU
  • MWS
  • NALP3
  • PYPAF1
  • AII/AVP
  • Cias1
  • Mmig1
  • Pypaf1
Epitope
C-Term
38
28
16
14
6
5
4
3
3
3
2
2
2
2
2
1
1
Reactivity
Human
160
35
29
6
5
4
2
1
1
Host
Goat
86
49
29
3
Clonality
Polyclonal
Conjugate
This NLRP3 antibody is un-conjugated
6
6
6
5
5
5
2
1
1
1
1
1
1
1
1
Methode Type
Peptide ELISA
Application
ELISA, Western Blotting (WB)
104
83
30
26
18
13
9
8
6
4
4
2
1
Supplier
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Immunogen Peptide with sequence C-EKPELTVVFEPSW, from the C Terminus of the protein sequence according to NP_001073289.1, NP_004886.3, NP_899632.1, NP_001120933.1, NP_001120934.1.
Blocking Peptide Blocking peptide for this product available: ABIN369010
Specificity Variants (NP_001073289.1, NP_004886.3) encode the same isoform.
Cross-Reactivity Rat (Rattus), Cow (Bovine)
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Alternative Name CIAS1 / cryopyrin (NLRP3 Antibody Abstract)
Background Synonyms: NLRP3, CIAS1, FCU, MWS, FCAS, NALP3, C1orf7, PYPAF1, AII/AVP, AGTAVPRL, CRYOPYRIN, cold autoinflammatory syndrome 1, cryopyrin, Muckle-Wells syndrome, chromosome 1 open reading frame 7, PYRIN-containing APAF1-like protein 1, neuronal apoptosis inhibitor protein 3, angiotensin/vasopressin receptor AII/AVP-like, NLR family, pyrin domain containing 3, AII, AVP, CLR1.1, FLJ95925, AII/AVP receptor-like, NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3, NACHT, LRR and PYD containing protein 3, PYRIN-containing APAF1-like protein 1, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3
Gene ID 114548
NCBI Accession NP_899632, NP_001073289, NP_004886, NP_001120934, NP_001120933
Application Notes ELISA: antibody detection limit dilution 1:32000.
Western blot: No signal obtained yet but low background observed in A431 lysates at up to 1 µg/mL. Flow cytometry: Customer finds it to work well in FC on human monocytes.
Restrictions For Research Use only
Format Liquid
Buffer Supplied at 0.5 mg/mL in Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Minimize freezing and thawing.
Storage -20 °C
Storage Comment Aliquot and store at -20 °C.
Background publications Hoffman, Mueller, Broide et al.: "Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome." in: Nature genetics, Vol. 29, Issue 3, pp. 301-5, 2001 (PubMed).