Retinoid X Receptor alpha antibody (Retinoid X Receptor, alpha) (Internal Region)

Details for Product anti-RXRA Antibody No. ABIN185295, Supplier: Log in to see
Antigen
  • RXRA
  • 9530071D11Rik
  • Nr2b1
  • RXRalpha1
  • NR2B1
  • RXRalpha
  • rxra-A
  • xRXR alpha
  • xrxra
  • RXR alpha
  • NR2B2-A
  • RXR
  • etID309733.19
  • rxrb
  • rxre
  • wu:fb93c09
  • retinoid X receptor, alpha
  • retinoid X receptor alpha
  • retinoid x receptor, beta a
  • RXRA
  • CpipJ_CPIJ010249
  • Rxra
  • rxra
  • rxrba
Alternatives
anti-Human Retinoid X Receptor alpha antibody for Electrophoretic Mobility-Shift Assay
Epitope
Internal Region
12
11
10
10
8
8
6
4
4
4
2
2
2
1
1
1
1
1
Reactivity
Human
86
23
20
10
8
7
6
6
5
3
2
2
2
2
Host
Goat
46
22
18
Clonality
Polyclonal
Conjugate
This Retinoid X Receptor alpha antibody is un-conjugated
3
3
3
3
3
3
Method Type
Peptide ELISA
Application
ELISA, Western Blotting (WB)
80
48
18
6
4
3
2
2
2
1
1
1
Options
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Immunogen Peptide with sequence CQVNSSLTSPTGRGSM, from the internal region of the protein sequence according to NP_002948.1.
Blocking Peptide Blocking peptide for this product available: ABIN369725
Specificity This antibody is expected to recognise an epitope corresponding to aa 14-28 of human RXR alpha protein and does not cross-react with either RXR beta or gamma.
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Alternative Name RXR alpha (RXRA Antibody Abstract)
Background Synonyms: RXRA, NR2B1, retinoid X receptor, alpha, FLJ16020, FLJ16733, MGC102720, FLJ00280, FLJ00318
Gene ID 6256
NCBI Accession NP_002948
Pathways Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha, Hepatitis C
Application Notes ELISA: antibody detection limit dilution 1:16000.
Western blot: Approx 55 kDa band observed in human epidermoid carcinoma A431 lysates (calculated MW of 50.8 kDa according to NP_002948). Recommended concentration: 0.5-3 µg/mL.
Restrictions For Research Use only
Format Liquid
Buffer Supplied at 0.5 mg/mL in Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Minimize freezing and thawing.
Storage -20 °C
Storage Comment Aliquot and store at -20 °C.
Supplier Images
 image for anti-Retinoid X Receptor alpha antibody (Retinoid X Receptor, alpha) (Internal Region) (ABIN185295) ABIN185295 (0.5µg/ml) staining of A431 lysate (35µg protein in RIPA buffer). Primary ...
Background publications Germain, Iyer, Zechel, Gronemeyer: "Co-regulator recruitment and the mechanism of retinoic acid receptor synergy." in: Nature, Vol. 415, Issue 6868, pp. 187-92, 2002 (PubMed).

Claudel, Leibowitz, Fiévet, Tailleux, Wagner, Repa, Torpier, Lobaccaro, Paterniti, Mangelsdorf, Heyman, Auwerx: "Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 5, pp. 2610-5, 2001 (PubMed).

Repa, Turley, Lobaccaro, Medina, Li, Lustig, Shan, Heyman, Dietschy, Mangelsdorf: "Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers." in: Science (New York, N.Y.), Vol. 289, Issue 5484, pp. 1524-9, 2000 (PubMed).