DYNLL1 antibody (Cytoplasmic)

Catalog No. ABIN187402

Product Details anti-DYNLL1 Antibody

Target: DYNLL1 (Dynein, Light Chain, LC8-Type 1 (DYNLL1))

Binding Specificity: Cytoplasmic

Reactivity: Human, Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This DYNLL1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Specificity: Recognizes human and mouse DLC1. Does not cross-react with DLC2. Species Reactivity: Mouse and human. Others not tested.

Immunogen: Recombinant mouse DLC1 [LC8, PIN].

Clone: 10D6

Isotype: IgM

Application Details

Application Notes: Flow Cytometry. Western blot: use at least a 1:1,000 dilution. The optimal dilution for a specific application should be determined by the researcher.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL.

Buffer: 100 µg affinity purified antibody in PBS containing 0.02% sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Target Details for DYNLL1

Target: DYNLL1 (Dynein, Light Chain, LC8-Type 1 (DYNLL1))

Alternative Name: DYNLL1 (DYNLL1 Products)

Synonyms: DLC1 antibody, DLC8 antibody, DNCL1 antibody, DNCLC1 antibody, LC8 antibody, LC8a antibody, PIN antibody, hdlc1 antibody, dynll2 antibody, wu:fd56c09 antibody, zgc:73406 antibody, Dlc8 antibody, Dnclc1 antibody, Pin antibody, 8kDLC antibody, lc8 antibody, dlc1 antibody, dlc8 antibody, lc8a antibody, dncl1 antibody, dnclc1 antibody, dynll1a antibody, MGC68763 antibody, CDLC2 antibody, dynll1 antibody, dynll1b antibody, pin antibody, MGC89636 antibody, dynein light chain LC8-type 1 antibody, dynein, light chain, LC8-type 1 antibody, dynein light chain LC8-type 1 S homeolog antibody, dynein light chain LC8-type 1 L homeolog antibody, Dynein light chain 1, cytoplasmic antibody, DYNLL1 antibody, dynll1 antibody, Dynll1 antibody, dynll1.S antibody, dynll1.L antibody, dlc-1 antibody

Background: The 10 kDa dynein light chain 1 (DLC1, LC8), also known as neuronal nitric oxide synthase inhibitory protein or PIN (protein inhibitor of nNOS), is a component of cytoplasmic dynein, which is involved in the minus end-directed movement of organelles along microtubules. It is a highly conserved protein that is associated with the microtubular dynein motor complex by its binding to dynein intermediate chain (DIC). This allows DLC1 to act as a cargo protein, hooking many different proteins to the dynein motor complex. Binding of the BH3-only protein, Bim, to DLC1 also controls its pro-apoptotic activity. In healthy cells, most Bim molecules are sequestered from Bcl-2 and its homologs by DLC1 mediated binding to the dynein motor complex. Certain apoptotic signals, such as cytokine withdrawal or deregulated calcium flux, induces the release of Bim and DLC1 from the dynein motor complex. This allows Bim and DLC1 to translocate and bind to Bcl-2 and its homologs, thus neutralizing their anti-apoptotic activity.

Pathways: M Phase, Tube Formation, Positive Regulation of Endopeptidase Activity