Cytochrome C, Somatic (CYCS) antibody

Antigen: Cytochrome C, Somatic (CYCS)

Synonyms: cycs, CYCS, CYC, HCS, THC4, cyc, hcs, cyct, MGC75709, MGC89066, DKFZp468F1016, MGC128356, CYCSA, MGC93634, Cyt-c1, CytC-1, CytC1, Cytc, Cytc-d, DC3, bln, bs30f07.y1, cyt c-d, cyt-c-d, cyt.c, cytochrome c, ms(2)04445, pDMc02, DmelCG13263, CG13263, Cyt-c2, CytC-2, Cytc-p, DC4, DMc01, cyt c-p, cyt-c-p, l(2)SH1590, pDMc01, DmelCG17903, CG17903

Clonality: Monoclonal (SJL2-4)

Host: Mouse

Reactivity: Goat, Human, Mouse (Murine), Rat (Rattus), Sheep (Ovine)

Application: Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)

Catalog no.: ABIN187410

Additional Information

Alternative name: Cytochrome c

Immunogen: Horse cytochrome c (aa.1-104).

Isotype: IgG2b  (Matching secondary antibodies)

Clone: SJL2-4

Description: Cytochrome c is translated by cytosolic ribosomes as apocytochrome c, and undergoes subsequent translocation into the mitochondria where a heme group is attached covalently to form holocytochrome c. Cytochrome c is important in the process of oxidative phosphorylation in mitochondria by participating in electron transport. Following exposure of a cell to an apoptotic stimuli, cytochrome c is released from mitochondria into the cytosol, binds Apaf-1 and stimulates activation of proapoptotic caspase-9 and -3. Bcl-2 and Bcl-xL prevent the release of cytochrome c and thereby inhibit apoptosis.

Specificity: Recognizes apocytochrome c. Species Reactivity: Human, mouse, rat, goat, sheep and monkey. Others not tested.

Synonyms: cycs, CYCS, CYC, HCS, THC4, cyc, hcs, cyct, MGC75709, MGC89066, DKFZp468F1016, MGC128356, CYCSA, MGC93634, Cyt-c1, CytC-1, CytC1, Cytc, Cytc-d, DC3, bln, bs30f07.y1, cyt c-d, cyt-c-d, cyt.c, cytochrome c, ms(2)04445, pDMc02, DmelCG13263, CG13263, Cyt-c2, CytC-2, Cytc-p, DC4, DMc01, cyt c-p, cyt-c-p, l(2)SH1590, pDMc01, DmelCG17903, CG17903

Application Details

Purity: 95% as determined by SDS-PAGE.

Buffer: 100 µg of monoclonal antibody at 1 mg/mL in PBS with 0.02% sodium azide.

Storage: Store at 4 °C.Do not freeze.

Research Area: Apoptosis/Necrosis, Metabolism

Restrictions: For Research Use only

Images

anti-Cytochrome C, Somatic (CYCS) antibody

anti-Cytochrome C, Somatic (CYCS) antibody (Image 2)