Apoptotic Chromatin Condensation Inducer 1 (ACIN1) antibody

Antigen: Apoptotic Chromatin Condensation Inducer 1 (ACIN1)

Synonyms: ACN, ACINUS, fSAP152, KIAA0670, DKFZp667N107, Acn, Acinus, C79325, acinusL, acinusS, mKIAA0670, 2610036I19Rik, 2610510L13Rik, acinus, acinusb, fi14c05, wu:fe06a10, wu:fi14c05, acinusa, acinusl, wu:fb04g06, wu:fb40f03, wu:fb68h03, wu:fb80f07, wu:fc12e10, ik:tdsubc_2g5, si:zc14a17.12, xx:tdsubc_2g5, acn, MGC69430, MGC132201

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB)

Catalog no.: ABIN187823

Additional Information

Alternative name: Acinus / ACIN1

Immunogen: Synthetic peptide corresponding to aa 1329-1341 of human AcinusL, aa 602-614 of human AcinusS' and aa 571-583 of human AcinusS. This sequence is identical to that of mouse acinus.

Description: Chromatin condensation and nuclear fragmentation (CCNF) is the hallmark of apoptosis. CCNF is triggered by the activation of members of the caspase family, caspase activated Dnase (CAD/DFF40), and several novel proteins including AIF and CIDE[1]. A new inducer of chromatin condensation was recently identified and designated acinus (for apoptotic chromatin condensation inducer in the nucleus). Acinus is cleaved by caspase-3 and an additional unknown protease generating a small active peptide p17, which causes chromatin condensation in vitro when it is added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Acinus is ubiquitously expressed. Three different spliced forms of acinus have been identified in human and mouse and designated acinusL, and acinusS, and acinusS'[2].

Specificity: Recognizes human acinus. Detects a band of ~220 kDa by Western blot. Species Reactivity: Human, other species not tested.

Synonyms: ACN, ACINUS, fSAP152, KIAA0670, DKFZp667N107, Acn, Acinus, C79325, acinusL, acinusS, mKIAA0670, 2610036I19Rik, 2610510L13Rik, acinus, acinusb, fi14c05, wu:fe06a10, wu:fi14c05, acinusa, acinusl, wu:fb04g06, wu:fb40f03, wu:fb68h03, wu:fb80f07, wu:fc12e10, ik:tdsubc_2g5, si:zc14a17.12, xx:tdsubc_2g5, acn, MGC69430, MGC132201

Application Details

Application Notes: Western blot: 0.25 - 0.5 µg/ml. The optimal dilution for a specific application should be determined by the researcher.

Buffer: 100 µg of purified IgG in 200 µl PBS containing 0.02% sodium azide.

Storage: Store at +4 °C.

Research Area: Cell Cycle, Apoptosis/Necrosis

Restrictions: For Research Use only

Images

anti-Apoptotic Chromatin Condensation Inducer 1 (ACIN1) antibody