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CDK2 antibody (AA 1-30)

CDK2 Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal RB7918 unconjugated
Catalog No. ABIN1881192
  • Target See all CDK2 Antibodies
    CDK2 (Cyclin-Dependent Kinase 2 (CDK2))
    Binding Specificity
    • 30
    • 28
    • 17
    • 16
    • 15
    • 10
    • 9
    • 8
    • 8
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-30
    Reactivity
    • 179
    • 97
    • 77
    • 10
    • 10
    • 8
    • 8
    • 6
    • 6
    • 6
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    Human
    Host
    • 184
    • 20
    • 1
    Rabbit
    Clonality
    • 171
    • 34
    Polyclonal
    Conjugate
    • 99
    • 19
    • 15
    • 10
    • 7
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    This CDK2 antibody is un-conjugated
    Application
    • 173
    • 77
    • 52
    • 50
    • 49
    • 39
    • 33
    • 26
    • 20
    • 13
    • 10
    • 8
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Predicted Reactivity
    B, Ha, M, Rat, X
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This CDK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from human CDK2.
    Clone
    RB7918
    Isotype
    Ig Fraction
    Top Product
    Discover our top product CDK2 Primary Antibody
  • Application Notes
    WB: 1:1000. IHC-P: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Moshinsky, Bellamacina, Boisvert, Huang, Hui, Jancarik, Kim, Rice: "SU9516: biochemical analysis of cdk inhibition and crystal structure in complex with cdk2." in: Biochemical and biophysical research communications, Vol. 310, Issue 3, pp. 1026-31, (2003) (PubMed).

    Chow, Siu, Ho, Ma, Ho, Poon: "Differential contribution of inhibitory phosphorylation of CDC2 and CDK2 for unperturbed cell cycle control and DNA integrity checkpoints." in: The Journal of biological chemistry, Vol. 278, Issue 42, pp. 40815-28, (2003) (PubMed).

    ONions, Allday: "Epstein-Barr virus can inhibit genotoxin-induced G1 arrest downstream of p53 by preventing the inactivation of CDK2." in: Oncogene, Vol. 22, Issue 46, pp. 7181-91, (2003) (PubMed).

    Yun, Chae, Choi, Kim, Bang, Chung, Choi, Mantovani, Shin: "Cdk2-dependent phosphorylation of the NF-Y transcription factor and its involvement in the p53-p21 signaling pathway." in: The Journal of biological chemistry, Vol. 278, Issue 38, pp. 36966-72, (2003) (PubMed).

    Izumiya, Lin, Ellison, Levy, Mayeur, Izumiya, Kung: "Cell cycle regulation by Kaposi's sarcoma-associated herpesvirus K-bZIP: direct interaction with cyclin-CDK2 and induction of G1 growth arrest." in: Journal of virology, Vol. 77, Issue 17, pp. 9652-61, (2003) (PubMed).

  • Target
    CDK2 (Cyclin-Dependent Kinase 2 (CDK2))
    Alternative Name
    CDK2 (CDK2 Products)
    Synonyms
    p33(CDK2) antibody, A630093N05Rik antibody, wu:fa10c02 antibody, zgc:56598 antibody, zgc:77684 antibody, eg1 antibody, CDKN2 antibody, cdk2L antibody, cyclin dependent kinase 2 antibody, cyclin-dependent kinase 2 antibody, cyclin-dependent kinase 2 S homeolog antibody, CDK2 antibody, Cdk2 antibody, cdk2 antibody, cdk2.S antibody
    Background
    CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and is regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation.
    Molecular Weight
    33930
    NCBI Accession
    NP_001789, NP_439892
    UniProt
    P24941
    Pathways
    PI3K-Akt Signaling, Cell Division Cycle, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Synthesis of DNA
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