CHRNB4 antibody (C-Term)

Catalog No. ABIN1881200

Product Details anti-CHRNB4 Antibody

Target: CHRNB4 (Cholinergic Receptor, Nicotinic, beta 4 (Neuronal) (CHRNB4))

Binding Specificity: AA 422-450, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHRNB4 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CHRNB4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 422-450 amino acids from the C-terminal region of human CHRNB4.

Clone: RB42408

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-CHRNB4 antibody (ABIN1881200)

Zhang, Kranzler, Poling, Gelernter: "Variation in the nicotinic acetylcholine receptor gene cluster CHRNA5-CHRNA3-CHRNB4 and its interaction with recent tobacco use influence cognitive flexibility." in: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, Vol. 35, Issue 11, pp. 2211-24, (2010) (PubMed).

Amos, Gorlov, Dong, Wu, Zhang, Lu, Scheet, Greisinger, Mills, Spitz: "Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study." in: Journal of the National Cancer Institute, Vol. 102, Issue 15, pp. 1199-205, (2010) (PubMed).

Saccone, Schwantes-An, Wang, Grucza, Breslau, Hatsukami, Johnson, Rice, Goate, Bierut: "Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans." in: Genes, brain, and behavior, Vol. 9, Issue 7, pp. 741-50, (2010) (PubMed).

Hansen, Xiao, Rice, Bracci, Wrensch, Sison, Chang, Smirnov, Patoka, Seldin, Quesenberry, Kelsey, Wiencke: "Fine mapping of chromosome 15q25.1 lung cancer susceptibility in African-Americans." in: Human molecular genetics, Vol. 19, Issue 18, pp. 3652-61, (2010) (PubMed).

Target Details for CHRNB4

Target: CHRNB4 (Cholinergic Receptor, Nicotinic, beta 4 (Neuronal) (CHRNB4))

Alternative Name: CHRNB4 (CHRNB4 Products)

Synonyms: Acrb-4 antibody, Acrb4 antibody, cholinergic receptor nicotinic beta 4 subunit antibody, cholinergic receptor, nicotinic, beta polypeptide 4 antibody, CHRNB4 antibody, Chrnb4 antibody

Background: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Molecular Weight: 56380

NCBI Accession: NP_000741, NP_001243496

UniProt: P30926