CSF2RA antibody (C-Term)

Catalog No. ABIN1881231

Product Details anti-CSF2RA Antibody

Target: CSF2RA (Colony Stimulating Factor 2 Receptor, Alpha, Low-Affinity (Granulocyte-Macrophage) (CSF2RA))

Binding Specificity: AA 366-394, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CSF2RA antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CSF2RA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 366-394 amino acids from the C-terminal region of human CSF2RA.

Clone: RB40748

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-CSF2RA antibody (ABIN1881231)

Mirza, Walker, Chen, Murphy, Young: "The Ig-like domain of human GM-CSF receptor alpha plays a critical role in cytokine binding and receptor activation." in: The Biochemical journal, Vol. 426, Issue 3, pp. 307-17, (2010) (PubMed).

Martinez-Moczygemba, Doan, Elidemir, Fan, Cheung, Lei, Moore, Tavana, Lewis, Zhu, Muzny, Gibbs, Huston: "Pulmonary alveolar proteinosis caused by deletion of the GM-CSFRalpha gene in the X chromosome pseudoautosomal region 1." in: The Journal of experimental medicine, Vol. 205, Issue 12, pp. 2711-6, (2008) (PubMed).

Hansen, Hercus, McClure, Stomski, Dottore, Powell, Ramshaw, Woodcock, Xu, Guthridge, McKinstry, Lopez, Parker: "The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation." in: Cell, Vol. 134, Issue 3, pp. 496-507, (2008) (PubMed).

Target Details for CSF2RA

Target: CSF2RA (Colony Stimulating Factor 2 Receptor, Alpha, Low-Affinity (Granulocyte-Macrophage) (CSF2RA))

Alternative Name: CSF2RA (CSF2RA Products)

Synonyms: CD116 antibody, CDw116 antibody, CSF2R antibody, CSF2RAX antibody, CSF2RAY antibody, CSF2RX antibody, CSF2RY antibody, GM-CSF-R-alpha antibody, GMCSFR antibody, GMR antibody, SMDP4 antibody, Csfgmra antibody, GM-CSF-Ra antibody, GM-CSFR antibody, colony stimulating factor 2 receptor, alpha antibody, colony stimulating factor 2 receptor alpha subunit antibody, colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) antibody, CSF2RA antibody, Csf2ra antibody

Background: The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble.

Molecular Weight: 46207

NCBI Accession: NP_001155001, NP_001155002, NP_001155003, NP_001155004, NP_006131, NP_758448, NP_758449, NP_758450, NP_758452

UniProt: P15509

Pathways: JAK-STAT Signaling