CSH1 antibody (N-Term)

Catalog No. ABIN1881233

Product Details anti-CSH1 Antibody

Target: CSH1 (Chorionic Somatomammotropin Hormone 1 (Placental Lactogen) (CSH1))

Binding Specificity: AA 42-70, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CSH1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CSH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-70 amino acids from the N-terminal region of human CSH1.

Clone: RB41664

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-CSH1 antibody (ABIN1881233)

Markl-Hahn, Neugebauer, Lenke, Ecker, Merz, McCook, Khoder, Brucker, Radermacher, Waller, Clapp, Bertsch, Triebel: "Human Placental Tissue Contains A Placental Lactogen-Derived Vasoinhibin." in: Journal of the Endocrine Society, Vol. 6, Issue 4, pp. bvac029, (2022) (PubMed).

Voorhees, Brooks: "Obligate ordered binding of human lactogenic cytokines." in: The Journal of biological chemistry, Vol. 285, Issue 26, pp. 20022-30, (2010) (PubMed).

Männik, Vaas, Rull, Teesalu, Rebane, Laan: "Differential expression profile of growth hormone/chorionic somatomammotropin genes in placenta of small- and large-for-gestational-age newborns." in: The Journal of clinical endocrinology and metabolism, Vol. 95, Issue 5, pp. 2433-42, (2010) (PubMed).

Davila, Froeling, Tan, Bonnard, Boland, Snippe, Hibberd, Seielstad: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, (2010) (PubMed).

Varvarigou, Liatsis, Vassilakos, Decavalas, Beratis: "Effect of maternal smoking on cord blood estriol, placental lactogen, chorionic gonadotropin, FSH, LH, and cortisol." in: Journal of perinatal medicine, Vol. 37, Issue 4, pp. 364-9, (2009) (PubMed).

Chen, Kibriya, Jasmine, Santella, Senie, Ahsan: "Do placental genes affect maternal breast cancer? Association between offspring's CGB5 and CSH1 gene variants and maternal breast cancer risk." in: Cancer research, Vol. 68, Issue 23, pp. 9729-34, (2008) (PubMed).

Target Details for CSH1

Target: CSH1 (Chorionic Somatomammotropin Hormone 1 (Placental Lactogen) (CSH1))

Alternative Name: CSH1 (CSH1 Products)

Synonyms: CS-1 antibody, CSA antibody, CSMT antibody, PL antibody, hCS-A antibody, CS-2 antibody, CSB antibody, hCS-B antibody, chorionic somatomammotropin hormone 1 antibody, chorionic somatomammotropin hormone 2 antibody, CSH1 antibody, CSH2 antibody

Background: The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation, an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome. [provided by RefSeq].

NCBI Accession: NP_001308, NP_066271

UniProt: P01243

Pathways: Response to Growth Hormone Stimulus