DYRK1A antibody (C-Term)

Catalog No. ABIN1881275

Product Details anti-DYRK1A Antibody

Target: DYRK1A (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A))

Binding Specificity: AA 718-745, C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DYRK1A antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Mouse Dyrk1a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 718-745 amino acids from the C-terminal region of mouse Dyrk1a.

Clone: RB40563

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-DYRK1A antibody (ABIN1881275)

Park, Oh, Yoo, Jung, Song, Lee, Seo, Chung: "Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells." in: The Journal of biological chemistry, Vol. 285, Issue 41, pp. 31895-906, (2010) (PubMed).

Kurabayashi, Hirota, Sakai, Sanada, Fukada: "DYRK1A and glycogen synthase kinase 3beta, a dual-kinase mechanism directing proteasomal degradation of CRY2 for circadian timekeeping." in: Molecular and cellular biology, Vol. 30, Issue 7, pp. 1757-68, (2010) (PubMed).

Guo, Williams, Schug, Li: "DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1." in: The Journal of biological chemistry, Vol. 285, Issue 17, pp. 13223-32, (2010) (PubMed).

Lee, Ha, Kim, Kim, Chang, Song, Kim: "Negative feedback Inhibition of NFATc1 by DYRK1A regulates bone homeostasis." in: The Journal of biological chemistry, Vol. 284, Issue 48, pp. 33343-51, (2009) (PubMed).

Target Details for DYRK1A

Target: DYRK1A (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A))

Alternative Name: Dyrk1a (DYRK1A Products)

Synonyms: DYRK1A antibody, dyrk antibody, dyrk1 antibody, hp86 antibody, mnb antibody, mnbh antibody, DYRK antibody, DYRK1 antibody, HP86 antibody, MNB antibody, MNBH antibody, MRD7 antibody, 2310043O08Rik antibody, D16Ertd272e antibody, D16Ertd493e antibody, Dyrk antibody, ENSMUSG00000074897 antibody, Gm10783 antibody, Mnbh antibody, Mp86 antibody, mmb antibody, PSK47 antibody, dual specificity tyrosine phosphorylation regulated kinase 1A antibody, dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A antibody, dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a antibody, dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A S homeolog antibody, DYRK1A antibody, dyrk1a antibody, Dyrk1a antibody, dyrk1a.S antibody

Background: Dyrk1a may play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.

Molecular Weight: 85494

NCBI Accession: NP_001106860, NP_031916

UniProt: Q61214

Pathways: Mitotic G1-G1/S Phases