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EIF3L antibody (N-Term)

EIF3L Reactivity: Human WB Host: Rabbit Polyclonal RB41025 unconjugated
Catalog No. ABIN1881291
  • Target See all EIF3L Antibodies
    EIF3L (Eukaryotic Translation Initiation Factor 3, Subunit L (EIF3L))
    Binding Specificity
    • 15
    • 13
    • 12
    • 2
    • 2
    • 1
    • 1
    AA 12-40, N-Term
    Reactivity
    • 39
    • 31
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 50
    Rabbit
    Clonality
    • 50
    Polyclonal
    Conjugate
    • 19
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This EIF3L antibody is un-conjugated
    Application
    • 27
    • 20
    • 13
    • 13
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB)
    Predicted Reactivity
    B, C, M, X
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This EIF3L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-40 amino acids from the N-terminal region of human EIF3L.
    Clone
    RB41025
    Isotype
    Ig Fraction
    Top Product
    Discover our top product EIF3L Primary Antibody
  • Application Notes
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Zhou, Sandercock, Fraser, Ridlova, Stephens, Schenauer, Yokoi-Fong, Barsky, Leary, Hershey, Doudna, Robinson: "Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 47, pp. 18139-44, (2008) (PubMed).

    Masutani, Sonenberg, Yokoyama, Imataka: "Reconstitution reveals the functional core of mammalian eIF3." in: The EMBO journal, Vol. 26, Issue 14, pp. 3373-83, (2007) (PubMed).

    Damoc, Fraser, Zhou, Videler, Mayeur, Hershey, Doudna, Robinson, Leary: "Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 7, pp. 1135-46, (2007) (PubMed).

  • Target
    EIF3L (Eukaryotic Translation Initiation Factor 3, Subunit L (EIF3L))
    Alternative Name
    EIF3L (EIF3L Products)
    Synonyms
    wu:fb66c05 antibody, zgc:64147 antibody, EIF3EIP antibody, EIF3S11 antibody, EIF3S6IP antibody, HSPC021 antibody, HSPC025 antibody, MSTP005 antibody, 0610011H21Rik antibody, D15N1e antibody, Eif3eip antibody, Eif3ip antibody, Eif3s6ip antibody, HSP-66Y antibody, PAF67 antibody, eif3eip antibody, eif3s6ip antibody, eukaryotic translation initiation factor 3, subunit 6 interacting protein antibody, eukaryotic translation initiation factor 3 subunit L antibody, eukaryotic translation initiation factor 3, subunit L antibody, eukaryotic translation initiation factor 3 subunit L L homeolog antibody, eif3s6ip antibody, EIF3L antibody, Eif3l antibody, eif3l.L antibody
    Background
    Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
    Molecular Weight
    66727
    NCBI Accession
    NP_001229852, NP_057175
    UniProt
    Q9Y262
    Pathways
    Ribonucleoprotein Complex Subunit Organization
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