This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This EIF4EBP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 87-115 amino acids from the C-terminal region of human EIF4EBP2.
EIF4EBP2
Reactivity: Human
ELISA
Host: Rabbit
Polyclonal
HRP
Application Notes
WB: 1:1000
Restrictions
For Research Use only
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Expiry Date
6 months
Bidinosti, Martineau, Frank, Sonenberg: "Repair of isoaspartate formation modulates the interaction of deamidated 4E-BP2 with mTORC1 in brain." in: The Journal of biological chemistry, Vol. 285, Issue 25, pp. 19402-8, (2010) (PubMed).
Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).
Gingras, Sonenberg: "Adenovirus infection inactivates the translational inhibitors 4E-BP1 and 4E-BP2." in: Virology, Vol. 237, Issue 1, pp. 182-6, (1997) (PubMed).
Target
eIF4EBP2 (EIF4EBP2)
(Eukaryotic Translation Initiation Factor 4E Binding Protein 2 (EIF4EBP2))
This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production through these gene products have been implicated in cell proliferation, cell differentiation and viral infection.