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FBXW4 antibody (C-Term)

FBXW4 Reactivity: Human WB Host: Rabbit Polyclonal RB42400 unconjugated
Catalog No. ABIN1881340
  • Target See all FBXW4 Antibodies
    FBXW4 (F-Box and WD Repeat Domain Containing 4 (FBXW4))
    Binding Specificity
    • 13
    • 13
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 341-370, C-Term
    Reactivity
    • 32
    • 12
    • 10
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    Human
    Host
    • 34
    • 2
    Rabbit
    Clonality
    • 36
    Polyclonal
    Conjugate
    • 17
    • 5
    • 4
    • 4
    • 3
    • 3
    This FBXW4 antibody is un-conjugated
    Application
    • 29
    • 27
    • 9
    • 4
    • 3
    • 3
    Western Blotting (WB)
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This FBXW4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 341-370 amino acids from the C-terminal region of human FBXW4.
    Clone
    RB42400
    Isotype
    Ig Fraction
    Top Product
    Discover our top product FBXW4 Primary Antibody
  • Application Notes
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Everman, Morgan, Lyle, Laughridge, Bamshad, Clarkson, Colby, Gurrieri, Innes, Roberson, Schrander-Stumpel, van Bokhoven, Antonarakis, Schwartz: "Frequency of genomic rearrangements involving the SHFM3 locus at chromosome 10q24 in syndromic and non-syndromic split-hand/foot malformation." in: American journal of medical genetics. Part A, Vol. 140, Issue 13, pp. 1375-83, (2006) (PubMed).

    Deloukas, Earthrowl, Grafham, Rubenfield, French, Steward, Sims, Jones, Searle, Scott, Howe, Hunt, Andrews, Gilbert, Swarbreck, Ashurst, Taylor, Battles, Bird, Ainscough, Almeida, Ashwell, Ambrose et al.: "The DNA sequence and comparative analysis of human chromosome 10. ..." in: Nature, Vol. 429, Issue 6990, pp. 375-81, (2004) (PubMed).

  • Target
    FBXW4 (F-Box and WD Repeat Domain Containing 4 (FBXW4))
    Alternative Name
    FBXW4 (FBXW4 Products)
    Synonyms
    dac antibody, hag antibody, hagoromo antibody, wu:fk63g06 antibody, FBXW4 antibody, DAC antibody, FBW4 antibody, FBWD4 antibody, SHFM3 antibody, SHSF3 antibody, Dac antibody, Fbw4 antibody, dactylin antibody, dactylyn antibody, F-box and WD repeat domain containing 4 antibody, F-box and WD-40 domain protein 4 antibody, fbxw4 antibody, FBXW4 antibody, Fbxw4 antibody
    Background
    This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds, disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22.
    Molecular Weight
    46337
    NCBI Accession
    NP_071322
    UniProt
    P57775
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