HIST2H2AC antibody (AA 18-46)

Catalog No. ABIN1881417

Product Details anti-HIST2H2AC Antibody

Target: HIST2H2AC (Histone Cluster 2, H2ac (HIST2H2AC))

Binding Specificity: AA 18-46

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HIST2H2AC antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: Rat, B, X, M, C, Pr, Zf, D

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This HIST2H2AC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-46 amino acids from the Central region of human HIST2H2AC.

Clone: RB41799

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-HIST2H2AC antibody (ABIN1881417)

Ishibashi, Dryhurst, Rose, Shabanowitz, Hunt, Ausió: "Acetylation of vertebrate H2A.Z and its effect on the structure of the nucleosome." in: Biochemistry, Vol. 48, Issue 22, pp. 5007-17, (2009) (PubMed).

Karaczyn, Cheng, Buzard, Hartley, Esposito, Kasprzak: "Truncation of histone H2A's C-terminal tail, as is typical for Ni(II)-assisted specific peptide bond hydrolysis, has gene expression altering effects." in: Annals of clinical and laboratory science, Vol. 39, Issue 3, pp. 251-62, (2009) (PubMed).

Zhao, Lang, Ito, Bonnet, Metzger, Sawatsubashi, Suzuki, Le Guezennec, Stunnenberg, Krasnov, Georgieva, Schüle, Takeyama, Kato, Tora, Devys: "A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing." in: Molecular cell, Vol. 29, Issue 1, pp. 92-101, (2008) (PubMed).

Target Details for HIST2H2AC

Target: HIST2H2AC (Histone Cluster 2, H2ac (HIST2H2AC))

Alternative Name: HIST2H2AC (HIST2H2AC Products)

Synonyms: HIST2H2AC antibody, H2A antibody, H2A-GL101 antibody, H2A/q antibody, H2AFQ antibody, H2a-613b antibody, RGD1560965 antibody, histone cluster 1, H2A, IV antibody, histone cluster 2 H2A family member c antibody, histone cluster 2, H2ac antibody, HIST1H2A4 antibody, HIST2H2AC antibody, Hist2h2ac antibody

Background: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family.

Molecular Weight: 13988

NCBI Accession: NP_003508

UniProt: Q16777