LATS2 antibody (C-Term)

Catalog No. ABIN1881491

Product Details anti-LATS2 Antibody

Target: LATS2 (LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2))

Binding Specificity: AA 1000-1027, C-Term

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LATS2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Mouse Lats2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1000-1027 amino acids from the C-terminal region of mouse Lats2.

Clone: RB40566

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000. IHC-P: 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-LATS2 antibody (ABIN1881491)

Oh, Lee, Kim, Kim, Oh, Hwang, Kong, Kwon, Lim: "Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse." in: Molecular and cellular biology, Vol. 29, Issue 23, pp. 6309-20, (2009) (PubMed).

Quina, Wang, Ng, Turner: "Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 29, Issue 45, pp. 14309-22, (2009) (PubMed).

Nishioka, Inoue, Adachi, Kiyonari, Ota, Ralston, Yabuta, Hirahara, Stephenson, Ogonuki, Makita, Kurihara, Morin-Kensicki, Nojima, Rossant, Nakao, Niwa, Sasaki: "The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass." in: Developmental cell, Vol. 16, Issue 3, pp. 398-410, (2009) (PubMed).

Matsui, Nakano, Shao, Gao, Luo, Hong, Zhai, Holle, Yu, Yabuta, Tao, Wagner, Nojima, Sadoshima: "Lats2 is a negative regulator of myocyte size in the heart." in: Circulation research, Vol. 103, Issue 11, pp. 1309-18, (2008) (PubMed).

Target Details for LATS2

Target: LATS2 (LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2))

Alternative Name: Lats2 (LATS2 Products)

Synonyms: 4932411G09Rik antibody, AV277261 antibody, AW228608 antibody, KPM antibody, lats2 antibody, large tumor suppressor kinase 2 antibody, large tumor suppressor 2 antibody, LATS2 antibody, Lats2 antibody, lats2 antibody

Background: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor (By similarity).

Molecular Weight: 115472

NCBI Accession: NP_056586

UniProt: Q7TSJ6