NPC1L1 antibody (N-Term)

Catalog No. ABIN1881583

Product Details anti-NPC1L1 Antibody

Target: NPC1L1 (NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1))

Binding Specificity: AA 294-323, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NPC1L1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This NPC1L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 294-323 amino acids from the N-terminal region of human NPC1L1.

Clone: RB42754

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-NPC1L1 antibody (ABIN1881583)

Teslovich, Musunuru, Smith, Edmondson, Stylianou, Koseki, Pirruccello, Ripatti, Chasman, Willer, Johansen, Fouchier, Isaacs, Peloso, Barbalic, Ricketts, Bis, Aulchenko, Thorleifsson, Feitosa et al.: "Biological, clinical and population relevance of 95 loci for blood lipids. ..." in: Nature, Vol. 466, Issue 7307, pp. 707-13, (2010) (PubMed).

Maeda, Honda, Ishikawa, Kinoshita, Mashimo, Takeoka, Yasuda, Kusano, Tsukamoto, Matsuzaki, Teramoto: "A SNP of NPC1L1 affects cholesterol absorption in Japanese." in: Journal of atherosclerosis and thrombosis, Vol. 17, Issue 4, pp. 356-60, (2010) (PubMed).

Hu, Lui, Mak, Chu, Lee, Poon, Tsui, Ko, Baum, Tam, Li, Tomlinson: "Pharmacogenetic analysis of lipid responses to rosuvastatin in Chinese patients." in: Pharmacogenetics and genomics, Vol. 20, Issue 10, pp. 634-7, (2010) (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).

Pramfalk, Jiang, Cai, Hu, Zhang, Han, Eriksson, Parini: "HNF1alpha and SREBP2 are important regulators of NPC1L1 in human liver." in: Journal of lipid research, Vol. 51, Issue 6, pp. 1354-62, (2010) (PubMed).

Target Details for NPC1L1

Target: NPC1L1 (NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1))

Alternative Name: NPC1L1 (NPC1L1 Products)

Synonyms: NPC1L1 antibody, 9130221N23Rik antibody, Gm243 antibody, NPC11L1 antibody, NPC1 like intracellular cholesterol transporter 1 antibody, NPC1 like 1 antibody, NPC1-like 1 antibody, NPC1L1 antibody, npc1l1 antibody, Npc1l1 antibody

Background: The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 148728

NCBI Accession: NP_001095118, NP_037521

UniProt: Q9UHC9