NR2E1 antibody (AA 75-102)

Catalog No. ABIN1881585

Product Details anti-NR2E1 Antibody

Target: NR2E1 (Nuclear Receptor Subfamily 2, Group E, Member 1 (NR2E1))

Binding Specificity: AA 75-102

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NR2E1 antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: C, M, X

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This NR2E1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 75-102 amino acids from the Central region of human NR2E1.

Clone: RB41747

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-NR2E1 antibody (ABIN1881585)

Liu, Wang, Belz, Bock, Takacs, Radlwimmer, Barbus, Reifenberger, Lichter, Schütz: "The nuclear receptor tailless induces long-term neural stem cell expansion and brain tumor initiation." in: Genes & development, Vol. 24, Issue 7, pp. 683-95, (2010) (PubMed).

Iwahara, Hisahara, Hayashi, Horio: "Transcriptional activation of NAD+-dependent protein deacetylase SIRT1 by nuclear receptor TLX." in: Biochemical and biophysical research communications, Vol. 386, Issue 4, pp. 671-5, (2009) (PubMed).

de Krom, Staal, Ophoff, Hendriks, Buitelaar, Franke, de Jonge, Bolton, Collier, Curran, van Engeland, van Ree: "A common variant in DRD3 receptor is associated with autism spectrum disorder." in: Biological psychiatry, Vol. 65, Issue 7, pp. 625-30, (2009) (PubMed).

Yokoyama, Takezawa, Schüle, Kitagawa, Kato: "Transrepressive function of TLX requires the histone demethylase LSD1." in: Molecular and cellular biology, Vol. 28, Issue 12, pp. 3995-4003, (2008) (PubMed).

Target Details for NR2E1

Target: NR2E1 (Nuclear Receptor Subfamily 2, Group E, Member 1 (NR2E1))

Alternative Name: NR2E1 (NR2E1 Products)

Synonyms: NR2E1 antibody, TLL antibody, TLX antibody, XTLL antibody, Mtl1 antibody, Mtll antibody, Tlx antibody, fierce antibody, frc antibody, tailless antibody, fc30e03 antibody, fc39f12 antibody, wu:fc30e03 antibody, wu:fc39f12 antibody, zgc:100991 antibody, Xtll antibody, nr2e1-A antibody, tlx antibody, nuclear receptor subfamily 2 group E member 1 antibody, nuclear receptor subfamily 2, group E, member 1 antibody, nuclear receptor subfamily 2 group E member 1 S homeolog antibody, NR2E1 antibody, Nr2e1 antibody, nr2e1 antibody, nr2e1.S antibody

Background: Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. May be required for brain development. May be involved in the regulation of retinal development (By similarity).

Molecular Weight: 42589

NCBI Accession: NP_003260

UniProt: Q9Y466

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Stem Cell Maintenance