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Neuregulin 3 antibody (AA 688-717)

NRG3 Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal RB2201 unconjugated
Catalog No. ABIN1881587
  • Target See all Neuregulin 3 (NRG3) Antibodies
    Neuregulin 3 (NRG3)
    Binding Specificity
    • 15
    • 8
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 688-717
    Reactivity
    • 26
    • 20
    • 8
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 40
    • 1
    Rabbit
    Clonality
    • 39
    • 2
    Polyclonal
    Conjugate
    • 15
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Neuregulin 3 antibody is un-conjugated
    Application
    • 29
    • 14
    • 13
    • 13
    • 11
    • 9
    • 3
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This NRG3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 688-717 amino acids of human NRG3.
    Clone
    RB2201
    Isotype
    IgG
    Top Product
    Discover our top product NRG3 Primary Antibody
  • Application Notes
    WB: 1:1000. IHC-P: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Wansbury, Panchal, James, Parry, Ashworth, Howard: "Dynamic expression of Erbb pathway members during early mammary gland morphogenesis." in: The Journal of investigative dermatology, Vol. 128, Issue 4, pp. 1009-21, (2008) (PubMed).

    Zhang, Sliwkowski, Mark, Frantz, Akita, Sun, Hillan, Crowley, Brush, Godowski: "Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 18, pp. 9562-7, (1997) (PubMed).

  • Target
    Neuregulin 3 (NRG3)
    Alternative Name
    NRG3 (NRG3 Products)
    Synonyms
    NRG3 antibody, HRG3 antibody, pro-NRG3 antibody, ska antibody, RGD1559678 antibody, neuregulin 3 antibody, pro-neuregulin-3, membrane-bound isoform antibody, NRG3 antibody, nrg3 antibody, LOC100478170 antibody, Nrg3 antibody
    Background
    NRG3, which belongs to the neuregulin family, is a direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. NRG3 does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. The protein exists as an type I membrane protein and as a proteolytically released soluble growth factor form. The membrane-bound form does not appear to be active. NRG3 is highly expressed in most regions of the brain with the exception of corpus callosum, and is expressed at lower level in testis. It is not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes. The NRG3 cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing may involve initial intracellular domain dimerization.
    Molecular Weight
    77901
    NCBI Accession
    NP_001010848, NP_001159445
    UniProt
    P56975
    Pathways
    RTK Signaling
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