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CDKN1B antibody (N-Term)

CDKN1B Reactivity: Human, Mouse WB Host: Rabbit Polyclonal RB42097 unconjugated
Catalog No. ABIN1881620
  • Target See all CDKN1B Antibodies
    CDKN1B (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))
    Binding Specificity
    • 29
    • 28
    • 22
    • 19
    • 17
    • 16
    • 11
    • 10
    • 9
    • 8
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-30, N-Term
    Reactivity
    • 274
    • 125
    • 106
    • 26
    • 6
    • 6
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Human, Mouse
    Host
    • 240
    • 49
    • 2
    • 1
    • 1
    Rabbit
    Clonality
    • 231
    • 62
    Polyclonal
    Conjugate
    • 143
    • 24
    • 17
    • 16
    • 16
    • 14
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This CDKN1B antibody is un-conjugated
    Application
    • 202
    • 134
    • 72
    • 62
    • 51
    • 41
    • 36
    • 26
    • 22
    • 16
    • 16
    • 13
    • 7
    • 7
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Predicted Reactivity
    Ha
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This p27Kip1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human p27Kip1.
    Clone
    RB42097
    Isotype
    Ig Fraction
    Top Product
    Discover our top product CDKN1B Primary Antibody
  • Application Notes
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Kajihara, Fukushige, Shioda, Tanabe, Fukunaga, Inui: "CaMKII phosphorylates serine 10 of p27 and confers apoptosis resistance to HeLa cells." in: Biochemical and biophysical research communications, Vol. 401, Issue 3, pp. 350-5, (2010) (PubMed).

    Kedde, van Kouwenhove, Zwart, Oude Vrielink, Elkon, Agami: "A Pumilio-induced RNA structure switch in p27-3' UTR controls miR-221 and miR-222 accessibility." in: Nature cell biology, Vol. 12, Issue 10, pp. 1014-20, (2010) (PubMed).

    Canbay, Eraltan, Cercel, Isbir, Gazioglu, Aydogan, Cacina, Cengiz, Ferahman, Zengin, Unal: "CCND1 and CDKN1B polymorphisms and risk of breast cancer." in: Anticancer research, Vol. 30, Issue 7, pp. 3093-8, (2010) (PubMed).

    Do Nascimento Borges, Burbano, Harada: "Absence of CIP1/KIP1 hypermethylation in gastric cancer patients from Northern Brazil." in: In vivo (Athens, Greece), Vol. 24, Issue 4, pp. 579-82, (2010) (PubMed).

  • Target
    CDKN1B (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))
    Alternative Name
    p27Kip1 (CDKN1B Products)
    Synonyms
    CDKN4 antibody, KIP1 antibody, MEN1B antibody, MEN4 antibody, P27KIP1 antibody, cdkn1b antibody, sb:cb611 antibody, wu:fb63g10 antibody, wu:fb64g10 antibody, wu:fe18e03 antibody, CDKN1B antibody, Kip1 antibody, p27 antibody, FAM14D antibody, ISG12 antibody, ISG12A antibody, P27 antibody, Cdki1b antibody, AA408329 antibody, AI843786 antibody, p27Kip1 antibody, cdkn1bl antibody, cyclin dependent kinase inhibitor 1B antibody, cyclin-dependent kinase inhibitor 1Bb antibody, interferon alpha inducible protein 27 antibody, cyclin-dependent kinase inhibitor 1B antibody, cyclin-dependent kinase inhibitor 1Ba antibody, CDKN1B antibody, cdkn1bb antibody, IFI27 antibody, Cdkn1b antibody, cdkn1ba antibody
    Background
    This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq].
    Molecular Weight
    22073
    NCBI Accession
    NP_004055
    UniProt
    P46527
    Pathways
    Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, Sensory Perception of Sound, Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Synthesis of DNA, Autophagy
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