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PARP1 antibody (AA 590-618)

PARP1 Reactivity: Human WB Host: Rabbit Polyclonal RB41491 unconjugated
Catalog No. ABIN1881628
  • Target See all PARP1 Antibodies
    PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))
    Binding Specificity
    • 20
    • 17
    • 16
    • 15
    • 12
    • 10
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 590-618
    Reactivity
    • 231
    • 64
    • 49
    • 8
    • 6
    • 6
    • 5
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 220
    • 27
    • 1
    • 1
    Rabbit
    Clonality
    • 207
    • 42
    Polyclonal
    Conjugate
    • 143
    • 17
    • 16
    • 16
    • 15
    • 14
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    This PARP1 antibody is un-conjugated
    Application
    • 160
    • 130
    • 69
    • 39
    • 34
    • 28
    • 28
    • 24
    • 24
    • 17
    • 16
    • 7
    • 7
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Predicted Reactivity
    B
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This PARP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 590-618 amino acids from the Central region of human PARP1.
    Clone
    RB41491
    Isotype
    Ig Fraction
    Top Product
    Discover our top product PARP1 Primary Antibody
  • Application Notes
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Dong, Bey, Li, Kabbani, Yan, Xie, Hsieh, Gao, Boothman: "Prostate cancer radiosensitization through poly(ADP-Ribose) polymerase-1 hyperactivation." in: Cancer research, Vol. 70, Issue 20, pp. 8088-96, (2010) (PubMed).

    Krishnakumar, Kraus: "PARP-1 regulates chromatin structure and transcription through a KDM5B-dependent pathway." in: Molecular cell, Vol. 39, Issue 5, pp. 736-49, (2010) (PubMed).

    Majewski, Thurston, Ramalingam, Kiela, Ghishan: "Cooperative role of NF-{kappa}B and poly(ADP-ribose) polymerase 1 (PARP-1) in the TNF-induced inhibition of PHEX expression in osteoblasts." in: The Journal of biological chemistry, Vol. 285, Issue 45, pp. 34828-38, (2010) (PubMed).

    Kim, Kang, Lee, Lee, Lee, Choi, Lee, Cho, Jin, Jheon, Son, Lee, Jung, Cha, Kim, Kang, Kam, Jung, Jheon, Park: "Comprehensive analysis of DNA repair gene polymorphisms and survival in patients with early stage non-small-cell lung cancer." in: Cancer science, Vol. 101, Issue 11, pp. 2436-42, (2010) (PubMed).

  • Target
    PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))
    Alternative Name
    PARP1 (PARP1 Products)
    Synonyms
    ADPRT antibody, ADPRT 1 antibody, ADPRT1 antibody, ARTD1 antibody, PARP antibody, PARP-1 antibody, PPOL antibody, pADPRT-1 antibody, Adprt antibody, Parp-1 antibody, 5830444G22Rik antibody, AI893648 antibody, Adprp antibody, Adprt1 antibody, C80510 antibody, parp-1 antibody, sPARP-1 antibody, BEST:LD21673 antibody, CG17685 antibody, CG17696 antibody, CG17718 antibody, CG40411 antibody, D.PARP antibody, Dm.pARTa antibody, Dmel\\CG40411 antibody, LD21673.3prime antibody, PARP1 antibody, dPARP antibody, parp antibody, adprt1 antibody, padprt-1 antibody, ppol antibody, si:dkey-206f10.3 antibody, wu:fc60f12 antibody, zgc:110092 antibody, poly(ADP-ribose) polymerase 1 antibody, poly (ADP-ribose) polymerase 1 antibody, poly (ADP-ribose) polymerase family, member 1 antibody, Poly-(ADP-ribose) polymerase antibody, poly(ADP-ribose) polymerase 1 L homeolog antibody, PARP1 antibody, Parp1 antibody, Parp antibody, parp1.L antibody, parp1 antibody
    Background
    This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
    Molecular Weight
    113084
    NCBI Accession
    NP_001609
    UniProt
    P09874
    Pathways
    Apoptosis, Caspase Cascade in Apoptosis, DNA Damage Repair, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location
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