PSMD12 antibody (AA 276-304)

Catalog No. ABIN1881697

Product Details anti-PSMD12 Antibody

Target: PSMD12 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 12 (PSMD12))

Binding Specificity: AA 276-304

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSMD12 antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: B

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PSMD12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 276-304 amino acids from the Central region of human PSMD12.

Clone: RB42427

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-PSMD12 antibody (ABIN1881697)

Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." in: Molecular systems biology, Vol. 3, pp. 89, (2007) (PubMed).

Gandhi, Zhong, Mathivanan, Karthick, Chandrika, Mohan, Sharma, Pinkert, Nagaraju, Periaswamy, Mishra, Nandakumar, Shen, Deshpande, Nayak, Sarker, Boeke, Parmigiani, Schultz, Bader, Pandey: "Analysis of the human protein interactome and comparison with yeast, worm and fly interaction datasets." in: Nature genetics, Vol. 38, Issue 3, pp. 285-93, (2006) (PubMed).

Listovsky, Oren, Yudkovsky, Mahbubani, Weiss, Lebendiker, Brandeis: "Mammalian Cdh1/Fzr mediates its own degradation." in: The EMBO journal, Vol. 23, Issue 7, pp. 1619-26, (2004) (PubMed).

Bouwmeester, Bauch, Ruffner, Angrand, Bergamini, Croughton, Cruciat, Eberhard, Gagneur, Ghidelli, Hopf, Huhse, Mangano, Michon, Schirle, Schlegl, Schwab, Stein, Bauer, Casari, Drewes, Gavin, Jackson et al.: "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. ..." in: Nature cell biology, Vol. 6, Issue 2, pp. 97-105, (2004) (PubMed).

Target Details for PSMD12

Target: PSMD12 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 12 (PSMD12))

Alternative Name: PSMD12 (PSMD12 Products)

Synonyms: wu:fb38a06 antibody, wu:fc34f08 antibody, wu:fc49f02 antibody, PSMD12 antibody, rpn5 antibody, Rpn5 antibody, p55 antibody, 1500002F15Rik antibody, AI480719 antibody, P55 antibody, proteasome 26S subunit, non-ATPase 12 antibody, proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 antibody, psmd12 antibody, PSMD12 antibody, Psmd12 antibody

Background: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3.

Molecular Weight: 52904

NCBI Accession: NP_002807, NP_777360

UniProt: O00232

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway