PSMD5 antibody (C-Term)

Catalog No. ABIN1881699

Product Details anti-PSMD5 Antibody

Target: PSMD5 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 5 (PSMD5))

Binding Specificity: AA 428-457, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSMD5 antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: B, M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PSMD5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 428-457 amino acids from the C-terminal region of human PSMD5.

Clone: RB40968

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-PSMD5 antibody (ABIN1881699)

Roelofs, Park, Haas, Tian, McAllister, Huo, Lee, Zhang, Shi, Gygi, Finley: "Chaperone-mediated pathway of proteasome regulatory particle assembly." in: Nature, Vol. 459, Issue 7248, pp. 861-5, (2009) (PubMed).

Kaneko, Hamazaki, Iemura, Sasaki, Furuyama, Natsume, Tanaka, Murata: "Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones." in: Cell, Vol. 137, Issue 5, pp. 914-25, (2009) (PubMed).

Listovsky, Oren, Yudkovsky, Mahbubani, Weiss, Lebendiker, Brandeis: "Mammalian Cdh1/Fzr mediates its own degradation." in: The EMBO journal, Vol. 23, Issue 7, pp. 1619-26, (2004) (PubMed).

Target Details for PSMD5

Target: PSMD5 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 5 (PSMD5))

Alternative Name: PSMD5 (PSMD5 Products)

Synonyms: S5B antibody, 1500032A03Rik antibody, AW475925 antibody, S5b antibody, W91691 antibody, mKIAA0072 antibody, proteasome 26S subunit, non-ATPase 5 antibody, proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 antibody, PSMD5 antibody, Psmd5 antibody

Background: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator base.

Molecular Weight: 56196

NCBI Accession: NP_001257356, NP_005038

UniProt: Q16401

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway