This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This PSPH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 7-36 amino acids from the N-terminal region of human PSPH.
PSPH
Reactivity: Human
WB
Host: Mouse
Polyclonal
unconjugated
Application Notes
WB: 1:1000. WB: 1:8000
Restrictions
For Research Use only
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Expiry Date
6 months
Lamesch, Li, Milstein, Fan, Hao, Szabo, Hu, Venkatesan, Bethel, Martin, Rogers, Lawlor, McLaren, Dricot, Borick, Cusick, Vandenhaute, Dunham, Hill, Vidal: "hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes." in: Genomics, Vol. 89, Issue 3, pp. 307-15, (2007) (PubMed).
Veiga-da-Cunha, Collet, Prieur, Jaeken, Peeraer, Rabbijns, Van Schaftingen: "Mutations responsible for 3-phosphoserine phosphatase deficiency." in: European journal of human genetics : EJHG, Vol. 12, Issue 2, pp. 163-6, (2004) (PubMed).
Peeraer, Rabijns, Verboven, Collet, Van Schaftingen, De Ranter: "High-resolution structure of human phosphoserine phosphatase in open conformation." in: Acta crystallographica. Section D, Biological crystallography, Vol. 59, Issue Pt 6, pp. 971-7, (2003) (PubMed).
The protein encoded by this gene belongs to a subfamily of the phosphotransferases. This encoded enzyme is responsible for the third and last step in L-serine formation. It catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine. Deficiency of this protein is thought to be linked to Williams syndrome.