SCARB1 antibody (N-Term)

Catalog No. ABIN1881777

Product Details anti-SCARB1 Antibody

Target: SCARB1 (Scavenger Receptor Class B, Member 1 (SCARB1))

Binding Specificity: AA 72-101, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SCARB1 antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: Pig

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SCARB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 72-101 amino acids from the N-terminal region of human SCARB1.

Clone: RB41754

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-SCARB1 antibody (ABIN1881777)

Kolmakova, Wang, Brogan, Chaffin, Rodriguez: "Deficiency of scavenger receptor class B type I negatively affects progesterone secretion in human granulosa cells." in: Endocrinology, Vol. 151, Issue 11, pp. 5519-27, (2010) (PubMed).

Teslovich, Musunuru, Smith, Edmondson, Stylianou, Koseki, Pirruccello, Ripatti, Chasman, Willer, Johansen, Fouchier, Isaacs, Peloso, Barbalic, Ricketts, Bis, Aulchenko, Thorleifsson, Feitosa et al.: "Biological, clinical and population relevance of 95 loci for blood lipids. ..." in: Nature, Vol. 466, Issue 7307, pp. 707-13, (2010) (PubMed).

Shimada, Miyagawa, Kawashima, Tanaka, Honda, Honda, Tokunaga: "An approach based on a genome-wide association study reveals candidate loci for narcolepsy." in: Human genetics, Vol. 128, Issue 4, pp. 433-41, (2010) (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).

Ruaño, Thompson, Kane, Pullinger, Windemuth, Seip, Kocherla, Holford, Wu: "Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?" in: Pharmacogenomics, Vol. 11, Issue 7, pp. 959-71, (2010) (PubMed).

Target Details for SCARB1

Target: SCARB1 (Scavenger Receptor Class B, Member 1 (SCARB1))

Alternative Name: SCARB1 (SCARB1 Products)

Synonyms: cb1015 antibody, SCARB1 antibody, Scarb1 antibody, CD36L1 antibody, CLA-1 antibody, CLA1 antibody, HDLQTL6 antibody, SR-BI antibody, SRB1 antibody, AI120173 antibody, CD36 antibody, Cd36l1 antibody, Cla-1 antibody, Cla1 antibody, D5Ertd460e antibody, Hdlq1 antibody, Hlb398 antibody, SR-B1 antibody, SRBI antibody, Srb1 antibody, mSR-BI antibody, scavenger receptor class B, member 1 antibody, scavenger receptor class B member 1 antibody, scarb1 antibody, SCARB1 antibody, Scarb1 antibody, CpipJ_CPIJ014332 antibody, CpipJ_CPIJ019101 antibody

Background: Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester (By similarity).

Molecular Weight: 60878

NCBI Accession: NP_005496

UniProt: Q8WTV0

Pathways: Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Lipid Metabolism, SARS-CoV-2 Protein Interactome