SMAD6 antibody (C-Term)

Catalog No. ABIN1881817

Product Details anti-SMAD6 Antibody

Target: SMAD6 (SMAD, Mothers Against DPP Homolog 6 (SMAD6))

Binding Specificity: AA 357-386, C-Term

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMAD6 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SMAD6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 357-386 amino acids from the C-terminal region of human SMAD6.

Clone: RB41931

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-SMAD6 antibody (ABIN1881817)

Ryan, Ryan, Fabre, Lawless, Crowe: "Defective bone morphogenic protein signaling underlies hepcidin deficiency in HFE hereditary hemochromatosis." in: Hepatology (Baltimore, Md.), Vol. 52, Issue 4, pp. 1266-73, (2010) (PubMed).

Yu, Mrowietz, Seifert: "Downregulation of SMAD2, 4 and 6 mRNA and TGFbeta receptor I mRNA in lesional and non-lesional psoriatic skin." in: Acta dermato-venereologica, Vol. 89, Issue 4, pp. 351-6, (2009) (PubMed).

Target Details for SMAD6

Target: SMAD6 (SMAD, Mothers Against DPP Homolog 6 (SMAD6))

Alternative Name: SMAD6 (SMAD6 Products)

Synonyms: madh6 antibody, madh7 antibody, Xsmad6 antibody, hst17432 antibody, AOVD2 antibody, HsT17432 antibody, MADH6 antibody, MADH7 antibody, Madh6 antibody, b2b390Clo antibody, Smad6-like antibody, smad6 antibody, wu:fb22g05 antibody, SMAD family member 6 antibody, SMAD family member 6a antibody, smad6 antibody, SMAD6 antibody, Smad6 antibody, smad6a antibody

Background: The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 53497

NCBI Accession: NP_001136333, NP_005576

UniProt: O43541

Pathways: Chromatin Binding