SMARCD1 antibody (AA 309-335)

Catalog No. ABIN1881818

Product Details anti-SMARCD1 Antibody

Target: SMARCD1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily D, Member 1 (SMARCD1))

Binding Specificity: AA 309-335

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMARCD1 antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: B, H

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Mouse Smarcd1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 309-335 amino acids from the Central region of mouse Smarcd1.

Clone: RB40713

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-SMARCD1 antibody (ABIN1881818)

Watanabe, Ui, Kanno, Ogiwara, Nagase, Kohno, Yasui: "SWI/SNF factors required for cellular resistance to DNA damage include ARID1A and ARID1B and show interdependent protein stability." in: Cancer research, Vol. 74, Issue 9, pp. 2465-75, (2014) (PubMed).

Guo, Huss, Tong, Wang, Li Sun, Clarke, Robson: "Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst." in: Developmental cell, Vol. 18, Issue 4, pp. 675-85, (2010) (PubMed).

Ho, Ronan, Wu, Staahl, Chen, Kuo, Lessard, Nesvizhskii, Ranish, Crabtree: "An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 13, pp. 5181-6, (2009) (PubMed).

Li, Liu, Li, Hao, Han, Hill, Vidal, Lin: "Genome-wide coactivation analysis of PGC-1alpha identifies BAF60a as a regulator of hepatic lipid metabolism." in: Cell metabolism, Vol. 8, Issue 2, pp. 105-17, (2008) (PubMed).

Oh, Sohn, Ko, Chung, Jeon, Seong: "BAF60a interacts with p53 to recruit the SWI/SNF complex." in: The Journal of biological chemistry, Vol. 283, Issue 18, pp. 11924-34, (2008) (PubMed).

Valerius, McMahon: "Transcriptional profiling of Wnt4 mutant mouse kidneys identifies genes expressed during nephron formation." in: Gene expression patterns : GEP, Vol. 8, Issue 5, pp. 297-306, (2008) (PubMed).

Target Details for SMARCD1

Target: SMARCD1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily D, Member 1 (SMARCD1))

Alternative Name: Smarcd1 (SMARCD1 Products)

Synonyms: rsc6p antibody, baf60a antibody, cracd1 antibody, MGC69403 antibody, BAF60A antibody, CRACD1 antibody, Rsc6p antibody, wu:fa10h07 antibody, wu:fb82d01 antibody, wu:fi45f10 antibody, AA407987 antibody, Baf60a antibody, D15Kz1 antibody, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 antibody, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 L homeolog antibody, SMARCD1 antibody, smarcd1 antibody, smarcd1.L antibody, Smarcd1 antibody

Background: Smarcd1 is involved in chromatin remodeling. Has a strong influence on the Vitamin D-mediated transcriptional activity from an enhancer Vitamin D receptor element (VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor (VDR) heterodimer. Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.

Molecular Weight: 58245

NCBI Accession: NP_114030

UniProt: Q61466