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TICAM1 antibody (N-Term)

TICAM1 Reactivity: Human, Mouse WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1881885
  • Target See all TICAM1 Antibodies
    TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))
    Binding Specificity
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 115-143, N-Term
    Reactivity
    • 26
    • 9
    • 3
    • 2
    Human, Mouse
    Host
    • 24
    • 3
    • 3
    Rabbit
    Clonality
    • 26
    • 4
    Polyclonal
    Conjugate
    • 23
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TICAM1 antibody is un-conjugated
    Application
    • 22
    • 7
    • 7
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This TICAM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-143 amino acids from the N-terminal region of human TICAM1.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product TICAM1 Primary Antibody
  • Application Notes
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Nakajima, Ohtani, Satta, Uno, Akari, Ishida, Kimura: "Natural selection in the TLR-related genes in the course of primate evolution." in: Immunogenetics, Vol. 60, Issue 12, pp. 727-35, (2008) (PubMed).

    Bin, Xu, Shu: "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling." in: The Journal of biological chemistry, Vol. 278, Issue 27, pp. 24526-32, (2003) (PubMed).

    Oshiumi, Matsumoto, Funami, Akazawa, Seya: "TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction." in: Nature immunology, Vol. 4, Issue 2, pp. 161-7, (2003) (PubMed).

    Matsuda, Suzuki, Honda, Muramatsu, Matsuzaki, Nagano, Doi, Shimotohno, Harada, Nishida, Hayashi, Sugano: "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways." in: Oncogene, Vol. 22, Issue 21, pp. 3307-18, (2003) (PubMed).

    Yamamoto, Sato, Mori, Hoshino, Takeuchi, Takeda, Akira: "Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 12, pp. 6668-72, (2002) (PubMed).

  • Target
    TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))
    Alternative Name
    TICAM1 (TICAM1 Products)
    Synonyms
    IIAE6 antibody, MyD88-3 antibody, PRVTIRB antibody, TICAM-1 antibody, TRIF antibody, AW046014 antibody, AW547018 antibody, trif antibody, toll like receptor adaptor molecule 1 antibody, toll-like receptor adaptor molecule 1 antibody, TICAM1 antibody, Ticam1 antibody, ticam1 antibody
    Background
    Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.
    Molecular Weight
    76422
    NCBI Accession
    NP_891549
    UniProt
    Q8IUC6
    Pathways
    TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades
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