USH1C antibody (N-Term)

Catalog No. ABIN1881984

Product Details anti-USH1C Antibody

Target: USH1C (Usher Syndrome 1C (Autosomal Recessive, Severe) (USH1C))

Binding Specificity: AA 1-30, N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This USH1C antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: B

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This USH1C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human USH1C.

Clone: RB41722

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-USH1C antibody (ABIN1881984)

Yan, Pan, Chen, Wu, Zhang: "The structure of the harmonin/sans complex reveals an unexpected interaction mode of the two Usher syndrome proteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 9, pp. 4040-5, (2010) (PubMed).

Jaijo, Aller, García-García, Aparisi, Bernal, Avila-Fernández, Barragán, Baiget, Ayuso, Antiñolo, Díaz-Llopis, Külm, Beneyto, Nájera, Millán: "Microarray-based mutation analysis of 183 Spanish families with Usher syndrome." in: Investigative ophthalmology & visual science, Vol. 51, Issue 3, pp. 1311-7, (2010) (PubMed).

Pan, Yan, Wu, Zhang: "Assembling stable hair cell tip link complex via multidentate interactions between harmonin and cadherin 23." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 14, pp. 5575-80, (2009) (PubMed).

Hanna, Kruskal, Ezekowitz, Bloom, Collier: "Role of macrophage oxidative burst in the action of anthrax lethal toxin." in: Molecular medicine (Cambridge, Mass.), Vol. 1, Issue 1, pp. 7-18, (1996) (PubMed).

Target Details for USH1C

Target: USH1C (Usher Syndrome 1C (Autosomal Recessive, Severe) (USH1C))

Alternative Name: USH1C (USH1C Products)

Synonyms: AIE-75 antibody, DFNB18 antibody, DFNB18A antibody, NY-CO-37 antibody, NY-CO-38 antibody, PDZ-45 antibody, PDZ-73 antibody, PDZ-73/NY-CO-38 antibody, PDZ73 antibody, PDZD7C antibody, ush1cpst antibody, 2010016F01Rik antibody, harmonin antibody, zgc:136806 antibody, ush1c antibody, USH1 protein network component harmonin antibody, harmonin antibody, Usher syndrome 1C antibody, USH1 protein network component harmonin L homeolog antibody, USH1C antibody, CpipJ_CPIJ012732 antibody, Ush1c antibody, ush1c antibody, ush1c.L antibody

Background: This gene encodes a scaffold protein that functions in the assembly of Usher protein complexes. The protein contains PDZ domains, a coiled-coil region with a bipartite nuclear localization signal and a PEST degradation sequence. Defects in this gene are the cause of Usher syndrome type 1C and non-syndromic sensorineural deafness autosomal recessive type 18. Multiple transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 62211

NCBI Accession: NP_005700, NP_710142

UniProt: Q9Y6N9

Pathways: Sensory Perception of Sound