YBX1 antibody (AA 149-178)

Catalog No. ABIN1882002

Product Details anti-YBX1 Antibody

Target: YBX1 (Y Box Binding Protein 1 (YBX1))

Binding Specificity: AA 149-178

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This YBX1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Predicted Reactivity: B, M, Rb, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This YBX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 149-178 amino acids from the Central region of human YBX1.

Clone: RB41913

Isotype: Ig Fraction

Application Details

Application Notes: IF: 1:10~50. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-YBX1 antibody (ABIN1882002)

Osada, Uno, Mineta, Kameoka, Takahashi, Terao: "Ancient genome-wide admixture extends beyond the current hybrid zone between Macaca fascicularis and M. mulatta." in: Molecular ecology, Vol. 19, Issue 14, pp. 2884-95, (2010) (PubMed).

Yu, Yip, Tan, Thike, Matsumoto, Tsujimoto, Bay: "Y-box binding protein 1 is up-regulated in proliferative breast cancer and its inhibition deregulates the cell cycle." in: International journal of oncology, Vol. 37, Issue 2, pp. 483-92, (2010) (PubMed).

Lovett, Cheng, Cape, Pollock, Mertens: "YB-1 alters MT1-MMP trafficking and stimulates MCF-7 breast tumor invasion and metastasis." in: Biochemical and biophysical research communications, Vol. 398, Issue 3, pp. 482-8, (2010) (PubMed).

Takahashi, Shimajiri, Izumi, Hirano, Kashiwagi, Yasuniwa, Wu, Han, Akiyama, Nishizawa, Sasaguri, Kohno: "Y-box binding protein-1 is a novel molecular target for tumor vessels." in: Cancer science, Vol. 101, Issue 6, pp. 1367-73, (2010) (PubMed).

To, Fotovati, Reipas, Law, Hu, Wang, Astanehe, Davies, Lee, Stratford, Raouf, Johnson, Berquin, Royer, Eaves, Dunn: "Y-box binding protein-1 induces the expression of CD44 and CD49f leading to enhanced self-renewal, mammosphere growth, and drug resistance." in: Cancer research, Vol. 70, Issue 7, pp. 2840-51, (2010) (PubMed).

Target Details for YBX1

Target: YBX1 (Y Box Binding Protein 1 (YBX1))

Alternative Name: YBX1 (YBX1 Products)

Synonyms: BP-8 antibody, CSDA2 antibody, CSDB antibody, DBPB antibody, MDR-NF1 antibody, NSEP-1 antibody, NSEP1 antibody, YB-1 antibody, YB1 antibody, Byb1 antibody, Cbfa antibody, Dbpb antibody, Ef1a antibody, Msy1 antibody, Nsep1 antibody, Yb1 antibody, bp-8 antibody, csda2 antibody, csdb antibody, dbpb antibody, frgy1 antibody, mdr-nf1 antibody, nsep-1 antibody, nsep1 antibody, yb1 antibody, 1700102N10Rik antibody, C79409 antibody, EF1A antibody, MSY1 antibody, dbpB antibody, mYB-1a antibody, nuclease sensitive element binding protein 1 antibody, Y-box binding protein 1 antibody, Y box binding protein 1 antibody, Y-box binding protein 1 S homeolog antibody, nuclease-sensitive element-binding protein 1 antibody, Y box protein 1 antibody, nsep1 antibody, YBX1 antibody, Ybx1 antibody, ybx1.S antibody, LOC479011 antibody

Background: Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as HLA class II genes. Regulates the transcription of numerous genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability.

Molecular Weight: 35924

NCBI Accession: NP_004550

UniProt: P67809

Pathways: Regulation of Muscle Cell Differentiation