PTPN1 antibody (N-Term)

Catalog No. ABIN1882122

Product Details anti-PTPN1 Antibody

Target: PTPN1 (Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1))

Binding Specificity: AA 23-53, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTPN1 antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: M, Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This PTP1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 23-53 amino acids from the N-terminal region of human PTP1B.

Clone: RB7011

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-PTPN1 antibody (ABIN1882122)

Trümpler, Schlott, Herrlich, Greer, Böhmer: "Calpain-mediated degradation of reversibly oxidized protein-tyrosine phosphatase 1B." in: The FEBS journal, Vol. 276, Issue 19, pp. 5622-33, (2009) (PubMed).

Xu, Li, Qian, Hong, Shen, Huang: "Reduction of PTP1B by RNAi upregulates the activity of insulin controlled fatty acid synthase promoter." in: Biochemical and biophysical research communications, Vol. 329, Issue 2, pp. 538-43, (2005) (PubMed).

Blincoe, Chidambaram, Salari, Bond, Evans, Gray-Kaufman, Griffey, Tranby, Garner-Johnson, Lee, Sorenson: "Pharmacokinetic distribution of 67Cu(II)2[3,5-diisopropyl(carboxy-14C)salicylate]4 among murine tissues." in: Current medicinal chemistry, Vol. 11, Issue 22, pp. 3007-15, (2004) (PubMed).

Wiesmann, Barr, Kung, Zhu, Erlanson, Shen, Fahr, Zhong, Taylor, Randal, McDowell, Hansen: "Allosteric inhibition of protein tyrosine phosphatase 1B." in: Nature structural & molecular biology, Vol. 11, Issue 8, pp. 730-7, (2004) (PubMed).

Kipfer-Coudreau, Eberlé, Sahbatou, Bonhomme, Guy-Grand, Froguel, Galan, Basdevant, Clément: "Single nucleotide polymorphisms of protein tyrosine phosphatase 1B gene are associated with obesity in morbidly obese French subjects." in: Diabetologia, Vol. 47, Issue 7, pp. 1278-84, (2004) (PubMed).

Palmer, Bento, Mychaleckyj, Langefeld, Campbell, Norris, Haffner, Bergman, Bowden: "Association of protein tyrosine phosphatase 1B gene polymorphisms with measures of glucose homeostasis in Hispanic Americans: the insulin resistance atherosclerosis study (IRAS) family study." in: Diabetes, Vol. 53, Issue 11, pp. 3013-9, (2004) (PubMed).

Target Details for PTPN1

Target: PTPN1 (Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1))

Alternative Name: PTP1B (PTPN1 Products)

Synonyms: PTPN1 antibody, PTP1B antibody, PTP-1B antibody, PTP-HA2 antibody, Ptp antibody, ptp1b antibody, wu:fk54h03 antibody, CPTP1 antibody, protein tyrosine phosphatase, non-receptor type 1 antibody, protein tyrosine phosphatase, non-receptor type 1 L homeolog antibody, PTPN1 antibody, Ptpn1 antibody, ptpn1 antibody, ptpn1.L antibody

Background: PTP1B is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation.

Molecular Weight: 49967

NCBI Accession: NP_001265547, NP_002818

UniProt: P18031

Pathways: TLR Signaling, Response to Growth Hormone Stimulus, ER-Nucleus Signaling, Platelet-derived growth Factor Receptor Signaling