YARS2 antibody (C-Term)

Catalog No. ABIN1882153

Product Details anti-YARS2 Antibody

Target: YARS2 (Tyrosyl-tRNA Synthetase 2, Mitochondrial (YARS2))

Binding Specificity: AA 399-427, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This YARS2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Predicted Reactivity: M, Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This YARS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 399-427 amino acids from the C-terminal region of human YARS2.

Clone: RB14936

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-YARS2 antibody (ABIN1882153)

Riley, Menezes, Rudinger-Thirion, Duff, de Lonlay, Rotig, Tchan, Davis, Cooper, Christodoulou: "Phenotypic variability and identification of novel YARS2 mutations in YARS2 mitochondrial myopathy, lactic acidosis and sideroblastic anaemia." in: Orphanet journal of rare diseases, Vol. 8, pp. 193, (2014) (PubMed).

Riley, Cooper, Hickey, Rudinger-Thirion, McKenzie, Compton, Lim, Thorburn, Ryan, Giegé, Bahlo, Christodoulou: "Mutation of the mitochondrial tyrosyl-tRNA synthetase gene, YARS2, causes myopathy, lactic acidosis, and sideroblastic anemia--MLASA syndrome." in: American journal of human genetics, Vol. 87, Issue 1, pp. 52-9, (2010) (PubMed).

Bonnefond, Frugier, Touzé, Lorber, Florentz, Giegé, Sauter, Rudinger-Thirion: "Crystal structure of human mitochondrial tyrosyl-tRNA synthetase reveals common and idiosyncratic features." in: Structure (London, England : 1993), Vol. 15, Issue 11, pp. 1505-16, (2007) (PubMed).

Target Details for YARS2

Target: YARS2 (Tyrosyl-tRNA Synthetase 2, Mitochondrial (YARS2))

Alternative Name: YARS2 (YARS2 Products)

Background: YARS2 catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).

Molecular Weight: 53199

NCBI Accession: NP_001035526

UniProt: Q9Y2Z4