Aurora Kinase C antibody (N-Term)

Catalog No. ABIN1882164

Product Details anti-Aurora Kinase C Antibody

Target: Aurora Kinase C (AURKC)

Binding Specificity: AA 3-38, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Aurora Kinase C antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This Aurora-C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-38 amino acids from the N-terminal region of human Aurora-C.

Clone: RB6507

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-Aurora Kinase C antibody (ABIN1882164)

Kimura, Matsuda, Yoshioka, Okano: "Cell cycle-dependent expression and centrosome localization of a third human aurora/Ipl1-related protein kinase, AIK3." in: The Journal of biological chemistry, Vol. 274, Issue 11, pp. 7334-40, (1999) (PubMed).

Tseng, Chen, Hsu, Tang: "Protein kinase profile of sperm and eggs: cloning and characterization of two novel testis-specific protein kinases (AIE1, AIE2) related to yeast and fly chromosome segregation regulators." in: DNA and cell biology, Vol. 17, Issue 10, pp. 823-33, (1998) (PubMed).

Bernard, Sanseau, Henry, Couturier, Prigent: "Cloning of STK13, a third human protein kinase related to Drosophila aurora and budding yeast Ipl1 that maps on chromosome 19q13.3-ter." in: Genomics, Vol. 53, Issue 3, pp. 406-9, (1998) (PubMed).

Target Details for Aurora Kinase C

Target: Aurora Kinase C (AURKC)

Alternative Name: Aurora-C (AURKC Products)

Synonyms: AURKC antibody, AIE2 antibody, AIK3 antibody, ARK3 antibody, AurC antibody, SPGF5 antibody, STK13 antibody, aurora-C antibody, AIE1 antibody, ARK-3 antibody, IAK3 antibody, Stk13 antibody, aurora kinase C antibody, AURKC antibody, Aurkc antibody

Background: Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases, members of the Ser/Thr protein kinase family, associate with microtubules during chromosome movement and segregation. Aurora kinase C may play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. This protein is localized to centrosome from anaphase to cytokinesis. Expression is limited to testis in normal cells. Elevated expression levels are seen only in a subset of cancer cells such as HepG2, HuH7 and HeLa cells. Aurora-C expression is maximum at M phase.

Molecular Weight: 35591

NCBI Accession: NP_001015878, NP_001015879, NP_003151

UniProt: Q9UQB9

Pathways: Cell Division Cycle, Maintenance of Protein Location