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UCHL1 antibody

UCHL1 Reactivity: Human, Rat WB, IHC (p) Host: Mouse Monoclonal 696CT2-1-4 unconjugated
Catalog No. ABIN1882287
  • Target See all UCHL1 Antibodies
    UCHL1 (Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1))
    Reactivity
    • 172
    • 95
    • 87
    • 45
    • 32
    • 18
    • 15
    • 15
    • 14
    • 14
    • 14
    • 12
    • 11
    • 7
    • 4
    • 1
    • 1
    • 1
    Human, Rat
    Host
    • 106
    • 68
    • 5
    • 3
    • 2
    Mouse
    Clonality
    • 100
    • 83
    Monoclonal
    Conjugate
    • 108
    • 14
    • 12
    • 7
    • 7
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This UCHL1 antibody is un-conjugated
    Application
    • 155
    • 62
    • 61
    • 40
    • 27
    • 22
    • 16
    • 14
    • 13
    • 11
    • 11
    • 7
    • 6
    • 3
    • 3
    • 2
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Predicted Reactivity
    B, Hs, Pr, M, Pig
    Purification
    This antibody is purified through a protein G column, followed by dialysis against PBS.
    Immunogen
    This UCHL1 Monoclonal antibody is generated from mouses immunized with a KLH conjugated synthetic peptide selected from the 185-214 region of human UCHL1.
    Clone
    696CT2-1-4
    Isotype
    IgG1
    Top Product
    Discover our top product UCHL1 Primary Antibody
  • Application Notes
    WB: 1:1000. IHC-P: 1:25. IHC-P: 1:25
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Boudreaux, Maiti, Davies, Das: "Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 20, pp. 9117-22, (2010) (PubMed).

    Hillier, Graves, Fulton, Fulton, Pepin, Minx, Wagner-McPherson, Layman, Wylie, Sekhon, Becker, Fewell, Delehaunty, Miner, Nash, Kremitzki, Oddy, Du, Sun, Bradshaw-Cordum, Ali, Carter, Cordes, Harris et al.: "Generation and annotation of the DNA sequences of human chromosomes 2 and 4. ..." in: Nature, Vol. 434, Issue 7034, pp. 724-31, (2005) (PubMed).

    Choi, Levey, Weintraub, Rees, Gearing, Chin, Li: "Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases." in: The Journal of biological chemistry, Vol. 279, Issue 13, pp. 13256-64, (2004) (PubMed).

    Day, Hinks, Thompson: "The structure of the human gene encoding protein gene product 9.5 (PGP9.5), a neuron-specific ubiquitin C-terminal hydrolase." in: The Biochemical journal, Vol. 268, Issue 2, pp. 521-4, (1990) (PubMed).

  • Target
    UCHL1 (Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1))
    Alternative Name
    UCHL1 (UCHL1 Products)
    Synonyms
    PARK5 antibody, PGP 9.5 antibody, PGP9.5 antibody, PGP95 antibody, Uch-L1 antibody, UCH-L1 antibody, UCHL1 antibody, cb358 antibody, wu:fc55h08 antibody, park5 antibody, pgp9.5 antibody, uch-l1 antibody, MGC132191 antibody, uchl1 antibody, AW822034 antibody, C88048 antibody, R75593 antibody, UCHL-1 antibody, gad antibody, ubiquitin C-terminal hydrolase L1 antibody, ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) antibody, ubiquitin C-terminal hydrolase L1 L homeolog antibody, ubiquitin carboxyl-terminal esterase L1 antibody, ubiquitin carboxy-terminal hydrolase L1 antibody, UCHL1 antibody, uchl1 antibody, uchl1.L antibody, LOC100304750 antibody, Uchl1 antibody
    Background
    Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.
    Molecular Weight
    24824
    NCBI Accession
    NP_004172
    UniProt
    P09936
    Pathways
    Feeding Behaviour
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