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Details for Product No. ABIN188687

Forkhead Box P2 (FOXP2) antibody

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Synonyms CAGH44, SPCH1, TNRC10, CAG-16, D0Kist7, AI449000, 2810043D05Rik, RGD1559697, FOXP2, cagh44, foxP2b, foxp2a, spch1, tnrc10, xlFoxP2, foxP2, foxP, Foxp2
»Alternatives Human, Rat (Rattus)
Clonality Polyclonal
»Alternatives Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN188687
Quantity 0.1 mg
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Immunogen Synthetic peptide, C-DEVEYQKRRSQKIT, representing the internal region of the humanprotein according to NP_055306.1, NP_683696.1, NP_683697.1, NP_683698.1. Reference Sequence: NP_055306.1, NP_683696.1, NP_683697.1, NP_683698.1.
Isotype IgG
Specificity Species Reactivity: Reacts with Human and rat. Expected from sequence similarity: Mouse and Canine.
Cross-Reactivity Human, Rat (Rattus)
Purification Affinity Purified
Alternative Name FOXP2
Background This gene encodes an evolutionarily conserved transcription factor expressed in fetaland adult brain. This transcription factor is a member of the forkhead/winged-helix(FOX) family of transcription factors, and contains a FOX DNA-binding domain and alarge polyglutamine tract. Members of the FOX family of transcription factors areregulators of embryogenesis. The product of this gene is thought to be required forproper development of speech and language regions of the brain during embryogenesis.Although a point mutation in this gene has been associated with the KE pedigreesegregating developmental verbal dyspraxia, no association between mutations in thisgene and another speech disorder, autism, has been found. Four alternative transcriptsencoding three different isoforms have been identified. Alternate Names: anti-FOXP2 antibody, anti-forkhead box P2antibody, anti-CAGH44 antibody,anti-DKFZp686H1726 antibody, anti-SPCH1 antibody, anti-TNRC10antibody, anti-CAGrepeat protein 44 antibody, anti-forkhead/winged-helix transcription factor antibody,anti-speech and language disorder 1 antibody, anti-trinucleotide repeat containing 10antibody.
Gene ID 93986, 500037
NCBI Accession NP_0553061
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Application Notes Peptide ELISA: antibody detection limit dilution 1:64,000. Western Blot: Approx 85kDaband observed in Human Brain (Cerebellum and Frontal Cortex) lysates and in RatBrain lysates (calculated MW of 82.6kDa according to NP_683696.1). Recommendedconcentration: 0.3-1ug/ml.An additional band of unknown identity was also consistently observed at 28-30kDa.This band was successfully blocked by incubation with the immunising peptide. Wewould appreciate any feedback from people in the field - have any such results beenreported with other antibodies/lysates? Have any further splice variants/modified formsbeen reported?
Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer Tris-saline [ pH7.3] with 0.5% BSA. Preservative: 0.02% sodium azide.
Preservative Sodium azide
Storage -20 °C
Lai, Fisher, Hurst et al.: "A forkhead-domain gene is mutated in a severe speech and language disorder." in: Nature, Vol. 413, Issue 6855, pp. 519-23, 2001 (PubMed).

Zhou, Zhong, Minoo et al.: "Foxp2 inhibits Nkx2.1-mediated transcription of SP-C via interactions with the Nkx2.1 homeodomain." in: American journal of respiratory cell and molecular biology, Vol. 38, Issue 6, pp. 750-8, 2008 (PubMed).

Prasad, Wang, Gray et al.: "A differential developmental pattern of spinal interneuron apoptosis during synaptogenesis: insights from genetic analyses of the protocadherin-gamma gene cluster." in: Development (Cambridge, England), Vol. 135, Issue 24, pp. 4153-64, 2008 (PubMed).

Alternatives for antigen "Forkhead Box P2 (FOXP2)", type "Antibodies"
Hosts (16), (14), (11)
Reactivities (35), (17), (9), (6), (4), (4), (1)
Applications (38), (23), (6), (5), (3), (2)
Epitopes (10), (5), (4), (4), (2), (2), (1), (1)