NLRP5 antibody (C-Term)

Catalog No. ABIN1886982

Product Details anti-NLRP5 Antibody

Target: NLRP5 (NLR Family, Pyrin Domain Containing 5 (NLRP5))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NLRP5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogen: 14 amino acid peptide near the carboxy terminus of human NALP5.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for NLRP5

Target: NLRP5 (NLR Family, Pyrin Domain Containing 5 (NLRP5))

Alternative Name: NALP5 (NLRP5 Products)

Synonyms: CLR19.8 antibody, MATER antibody, NALP5 antibody, PAN11 antibody, PYPAF8 antibody, Mater antibody, Nalp5 antibody, Op1 antibody, NLR family pyrin domain containing 5 antibody, NLR family, pyrin domain containing 5 antibody, NLRP5 antibody, Nlrp5 antibody

Background: NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction.NALP5, also known as MATER, is a maternal gene required for early embryonic development in mice.Increased NALP5 expression was observed in two neuronal injury models, and transient expression of recombinant NALP5 in neurons induced caspase-3 activation and apoptosis, suggesting that NALP5 also plays a role in caspase activation and apoptosis in injured neurons, and may thus represent a novel target for therapeutic treatment in neurodegenerative disorders.
Synonyms: NLR family pyrin domain containing 5, NLRP5, MATER, PYRIN-containing APAF1-like protein 8, PYPAF8, CLR19.8, PAN11

NCBI Accession: NP_703148

Pathways: Inflammasome