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SYPL2 antibody (C-Term)

SYPL2 Reactivity: Human, Mouse, Rat ELISA, WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1887064
  • Target See all SYPL2 Antibodies
    SYPL2 (Synaptophysin-Like 2 (SYPL2))
    Binding Specificity
    C-Term
    Reactivity
    Human, Mouse, Rat
    Host
    • 2
    Rabbit
    Clonality
    • 2
    Polyclonal
    Conjugate
    • 2
    This SYPL2 antibody is un-conjugated
    Application
    • 2
    • 2
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
    Cross-Reactivity (Details)
    At least two isoforms of SYPL2 are known to exist. SYPL2 antibody will not cross-react with SYPL1.
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    15 amino acid peptide near the carboxy terminus of human SYPL.
    Top Product
    Discover our top product SYPL2 Primary Antibody
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
    Handling Advice
    Avoid freezing and thawing repeatly.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 4 °C for short term use.Store at -20 °C for long term preservation.
  • Target
    SYPL2 (Synaptophysin-Like 2 (SYPL2))
    Alternative Name
    SYPL2 (SYPL2 Products)
    Synonyms
    AI552439 antibody, Mg29 antibody, MG29 antibody, mg29 antibody, MGC88982 antibody, Sypl antibody, fc22a07 antibody, wu:fc22a07 antibody, zgc:110355 antibody, sypl antibody, wu:fd54d09 antibody, zgc:65838 antibody, synaptophysin-like 2 antibody, synaptophysin like 2 antibody, synaptophysin like 2 S homeolog antibody, synaptophysin-like 2b antibody, synaptophysin-like 2a antibody, Sypl2 antibody, SYPL2 antibody, sypl2.S antibody, sypl2 antibody, sypl2b antibody, sypl2a antibody
    Background
    SYPL2, also known as Mitsugumin 29, was initially identified as a transmembrane protein from the triad junction in skeletal muscle that had significant homology with members of the synaptophysin family.SYPL2 is thought to participate in the excitation-contraction coupling process of skeletal muscle as SYPL2-null mice showed reduced muscle contractile force and altered triad junction structure and increased susceptibility to fatigue of the skeletal muscle.SYPL2 plays a critical role in muscle Ca2+ signaling by regulating the process of store-operated Ca2+ entry and interacts with ryanodine receptor (RyR), thereby influencing intracellular Ca2+ homeostasis through changes in the RyR/Ca2+ release function.Co-expression of SYPL2 and RyR in cultured cells leads to apoptotic cell death resulting from the depletion of Ca2+ from the intracellular stores.
    Synonyms: SYPL2, Synaptophysin-like protein 2, mitsugumin 29, MG29
    NCBI Accession
    NP_001035799
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