ZFYVE26 antibody (C-Term)

Catalog No. ABIN1887150

Product Details anti-ZFYVE26 Antibody

Target: ZFYVE26 (Zinc Finger, FYVE Domain Containing 26 (ZFYVE26))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZFYVE26 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Purification: Affinity chromatography purified via peptide column

Immunogen: 16 amino acid peptide near the carboxy terminus of human SPG15.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for ZFYVE26

Target: ZFYVE26 (Zinc Finger, FYVE Domain Containing 26 (ZFYVE26))

Alternative Name: SPG15 (ZFYVE26 Products)

Synonyms: wu:fc33a03 antibody, FYVE-CENT antibody, SPG15 antibody, 4930465A13 antibody, 9330197E15Rik antibody, A630028O16Rik antibody, Gm893 antibody, mKIAA0321 antibody, zinc finger, FYVE domain containing 26 antibody, zinc finger FYVE-type containing 26 antibody, zfyve26 antibody, ZFYVE26 antibody, Zfyve26 antibody

Background: Hereditary spastic paraplegias (HSPs) are genetically and phenotypically heterogeneous disorders.? Spastic paraplegia with thinning of the corpus callosum (ARHSP-TCC) is a relatively frequent form of complicated hereditary spastic paraplegia in which mental retardation and muscle stiffness at onset are followed by slowly progressive paraparesis and cognitive deterioration.SPG15 is the second gene known to be responsible for ARHSP-TCC in the Italian population.Mutations in this gene are associated with autosomal recessive spastic paraplegia-15.SPG15 encodes a protein containing a FYVE zinc finger binding domain which is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane.SPG15 mRNA is widely distributed in human tissues, as well as in rat embryos, suggesting a possible role for this protein during embryonic development.SPG15 co-localizes partially with endoplasmic reticulum and endosome markers, suggesting a role in intracellular trafficking.Multiple isoforms of SPG15 are known to exist.
Synonyms: Autosomal recessive spastic paraplegia 15, ZFYVE26