TMEM59L antibody (C-Term)

Catalog No. ABIN1887271

Product Details anti-TMEM59L Antibody

Target: TMEM59L (Transmembrane Protein 59-Like (TMEM59L))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMEM59L antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity (Details): Multiple isoforms of TMEM59L are known to exist. TMEM59L antibody is predicted to not cross-react TMEM59.

Purification: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid peptide near carboxy terminus of human TMEM59L.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for TMEM59L

Target: TMEM59L (Transmembrane Protein 59-Like (TMEM59L))

Alternative Name: TMEM59L (TMEM59L Products)

Synonyms: LOC719572 antibody, BSMAP antibody, C19orf4 antibody, 5330410G16Rik antibody, RGD1305557 antibody, transmembrane protein 59 like antibody, transmembrane protein 59-like antibody, TMEM59L antibody, Tmem59l antibody

Background: Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis.TMEM59L is a type I membrane glycoprotein that is expressed in the brain.A related protein, TMEM59, is a Golgi-localized protein that modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP and inhibits APP transport and shedding.
Synonyms: Transmembrane protein 59L, brain-specific membrane-anchored protein, BSMAP

NCBI Accession: NP_036241