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PHAP I antibody (C-Term)

Reactivity: Human, Mouse, Rat WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1887420
  • Target See all PHAP I products
    PHAP I
    Binding Specificity
    C-Term
    Reactivity
    Human, Mouse, Rat
    Host
    • 2
    Rabbit
    Clonality
    • 2
    Polyclonal
    Conjugate
    • 2
    This PHAP I antibody is un-conjugated
    Application
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Cross-Reactivity (Details)
    This polyclonal antibody has no cross-reaction to PHAP I2a and PHAP III.
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    PHAP I antibody was raised with a Synthetic peptide corresponding to amino acids at carboxy terminus of human PHAP I.
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
    Handling Advice
    Avoid freezing and thawing repeatly.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 4 °C for short term use.Store at -20 °C for long term preservation.
  • Target
    PHAP I
    Abstract
    PHAP I Products
    Background
    Apoptosis is related to many diseases and development.Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators.Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9.Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis.The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis.PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway.PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.
    Molecular Weight
    32 kDa
    UniProt
    P39687
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