PRR5L antibody (Center)

Catalog No. ABIN1887660

Product Details anti-PRR5L Antibody

Target: PRR5L (Proline Rich 5 Like (PRR5L))

Binding Specificity: Center

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRR5L antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity (Details): At least three isoforms of PRR5L are known to exist, this antibody will recognize only isoforms a and b. PRR5L antibody will not cross-react with PPR5.

Purification: Affinity chromatography purified via peptide column

Immunogen: 17 amino acid peptide near the center of human PRR5L.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for PRR5L

Target: PRR5L (Proline Rich 5 Like (PRR5L))

Alternative Name: PRR5L (PRR5L Products)

Synonyms: PROTOR2 antibody, 2600010E01Rik antibody, 4833411O04Rik antibody, Protor-2 antibody, Protor2 antibody, RGD1309969 antibody, PRR5L antibody, FLJ14213 antibody, proline rich 5 like antibody, PRR5L antibody, Prr5l antibody, prr5l antibody

Background: Proline-rich protein 5-like (PRR5L), also known as Protor-2, is structurally similar to PRR5 and also binds to the mTOR complex 2 (mTORC2).PRR5L is not required for mTORC2 integrity or kinase activity, but dissociates from mTORC2 upon knockdown of tuberous sclerosis complex 1 (TSC1) and TSC2.Knockdown of PRR5L reduced apoptosis in mTORC2 deficient cells as well as cells where mTOR was active, suggesting that mTORC2-dissociated PRR5L may promote apoptosis, and thus play a role in the balance between cell growth and cell death.
Synonyms: Proline-rich protein 5-like, Protor-2, PROTOR2

NCBI Accession: NP_001153639