NLRC3 antibody (Center)

Catalog No. ABIN1887754

Product Details anti-NLRC3 Antibody

Target: NLRC3 (NLR Family, CARD Domain Containing 3 (NLRC3))

Binding Specificity: Center

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NLRC3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Affinity chromatography purified via peptide column

Immunogen: NOD3 antibody was raised against an 18 amino acid peptide near the center of human NOD3.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for NLRC3

Target: NLRC3 (NLR Family, CARD Domain Containing 3 (NLRC3))

Alternative Name: NOD3 (NLRC3 Products)

Synonyms: NLRC3 antibody, nod3 antibody, NLR-A3 antibody, NOD3 antibody, CLR16.2 antibody, D230007K08Rik antibody, mFLJ00348 antibody, Nlrc3-ps1 antibody, RGD1304902 antibody, NLR family CARD domain containing 3 antibody, NLR family, CARD domain containing 3 antibody, NLRC3 antibody, nlrc3 antibody, Nlrc3 antibody

Background: NOD3 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense.NOD3 also known as NLR family CARD containing 3 (NLRC3), is predominantly expressed in the immune system, particularly in T lymphocytes, and its expression is strongly down-regulated following stimulation of the T-cell receptor complex and CD28, suggesting that NOD3 plays a role in attenuating the activation of T cells.NOD3 inhibits NF-kappaB, AP-1 and NFAT transcriptional activation in Jurkat T cells downstream of CD3/CD28 stimulation or treatment with PMA/ionomycin and decreases IL-2 and CD25 mRNA induction in activated cells.
Synonyms: Nucleotide-binding oligomerization domain containing 3, NLRC3, CLR16.2