DACT2 antibody (N-Term)

Catalog No. ABIN1887827

Product Details anti-DACT2 Antibody

Target: DACT2 (Dapper, Antagonist of beta-Catenin 2 (DACT2))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DACT2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogen: 12 amino acid peptide from near the amino terminus of human DACT2.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for DACT2

Target: DACT2 (Dapper, Antagonist of beta-Catenin 2 (DACT2))

Alternative Name: Dact2 (DACT2 Products)

Synonyms: 2900084M21Rik antibody, A630024E20 antibody, Dpr2 antibody, Frd2 antibody, dapper2 antibody, C6orf116 antibody, DAPPER2 antibody, DPR2 antibody, RP11-503C24.7 antibody, bA503C24.7 antibody, dishevelled binding antagonist of beta catenin 2 antibody, dishevelled-binding antagonist of beta-catenin 2 antibody, DACT2 antibody, Dact2 antibody

Background: The Wnt signaling cascade is a conserved process in multicellular animals that plays important roles during development and can contribute to cancer and other diseases.Many members of this pathway are also expressed in the postnatal tissues such as brain.One such protein is Dact2, a member of the Dact protein family that was initially identified through binding to Disheveled (Dvl), a cytoplasmic protein essential to Wnt signaling.Dact2 is most prominent during the development of the thymus kidneys, and salivary gland.Dact2 is thought to play a role distinct from that of Dact1 with Dact2 having a greater impact on a beta-catenin-independent process termed planar cell polarity/convergent-extension signaling.Furthermore, Dact2 but not Dact1 can inhibit Nodal signaling by promoting the endocytic degradation of TGF-beta receptors.At least two isoforms of Dact2 are known to exist.
Synonyms: Dapper homolog 2, Dapper antagonist of beta-catenin 2

NCBI Accession: NP_999627